Anais Brasileiros de Dermatologia - Vol.97 num.2

Continuing Medical Education 1
Cutaneous tuberculosis: epidemiological, clinical, diagnostic and therapeutic update 1
Introduction 1
Etiology and pathogenesis 2
Clinical manifestations and classification 3
Tuberculous chancre 3
Clinical manifestations 3
Histopathology 3
Diagnosis 3
Differential diagnosis 3
Tuberculosis verrucosa cutis 4
Clinical manifestations 4
Histopathology 4
Diagnosis 4
Differential diagnosis 4
Scrofuloderma 4
Clinical manifestations 4
Histopathology 4
Diagnosis 6
Differential diagnosis 6
Tuberculosis orificalis 6
Clinical manifestations 6
Histopathology 6
Diagnosis 6
Differential diagnosis 6
Lupus vulgaris 6
Clinical manifestations 6
Histopathology 6
Diagnosis 7
Differential diagnosis 7
Acute miliary tuberculosis 7
Clinical manifestations 8
Histopathology 8
Diagnosis 8
Differential diagnosis 8
Gummatous tuberculosis 8
Clinical manifestations 8
Histopathology 8
Diagnosis 8
Differential diagnosis 8
Cutaneous tuberculosis after BCG vaccination (Bacillus Calmette-Guerin) 8
Tuberculids 8
Papulonecrotic tuberculid 9
Clinical manifestations 10
Histopathology 10
Diagnosis 10
Differential diagnosis 10
Lichenoid tuberculid or lichen scrofulosorum 10
Clinical manifestations 10
Histopathology 10
Differential diagnosis 10
Erythema induratum of Bazin and nodular vasculitis 10
Epidemiology 10
Pathogenesis 11
Clinical manifestations 11
Histopathology 12
Diagnosis 12
Differential diagnosis 12
Diagnosis of cutaneous tuberculosis 12
Interferon-gamma release assay 13
Tests available in Brazil: QuantiFERON-TB Gold Plus (QTF-G) and T-SPOT.TB 13
CTB treatment 13
Immunobiologicals and latent tuberculosis 13
Financial support 14
Authors contributions 14
Conflicts of interest 14
References 14
Original Articles 17
Autoantibodies against desmoglein 2 are not pathogenic in pemphigus 17
Introduction 18
Materials and methods 18
Ethics 18
Study population 18
Detection of IgG autoantibodies against Dsg1 and Dsg3 by ELISA 18
Detection of IgG autoantibodies against Dsg2 by in-house ELISA 18
Adsorption ELISA for anti-Dsg2 specificity 20
Biopsy samples 20
Immunohistochemistry (IHC) 21
RNA extraction and cDNA synthesis 21
Real-time quantitative polymerase chain reaction (qPCR) and sequencing of Dsg1, Dsg2 and Dsg3 21
Statistical analysis 21
Results 21
Protein expression of desmogleins by IHC 23
Gene expression of desmogleins by qPCR 24
Discussion 24
Study limitations 27
Conclusion 27
Submission and verification statement 27
Financial support 27
Authors contributions 27
Conflicts of interest 27
Acknowledgments 27
Appendix A Supplementary data 27
References 28
Efficacy of sunscreen with photolyase or regular sunscreen associated with topical antioxidants in treating advanced photo... 29
Introduction 30
Methods 30
Type of study 30
Participants 30
Interventions 30
Outcomes 32
Sample calculation 32
Randomisation and evaluations 32
Statistical analysis 32
Results 32
Safety and tolerability 33
Discussion 33
Conclusions 35
Financial support 35
Authors contributions 35
Conflicts of interest 36
References 36
Pediatric androgenetic alopecia: a retrospective review of clinical characteristics, hormonal assays and metabolic syndrom... 38
Introducton 39
Methods 39
Results 40
Dscusson 40
Concluson 43
Financial support 44
Authors' contributions 44
Conflicts of interest 44
References 44
Validation and reproducibility of the International Study of Asthma and Allergies in Childhood (ISAAC) Written Atopic Ecze... 45
Introduction 46
Methods 46
Results 47
Discussion 48
Conclusion 49
Financial support 49
Authors contributions 49
Conflicts of interest 50
References 50
Case Reports 51
Primary cutaneous B-cell lymphoma leg type: good response with the RADHAP 21 protocol 51
Introduction 51
Case report 52
Discussion 54
Financial support 55
Authors' contributions 55
Conflicts of interest 55
References 55
Severe varicella in a child immunosuppressed with methotrexate 56
Introduction 56
Case report 57
Discussion 58
Financial support 58
Authors' contributions 58
Conflicts of interest 60
References 60
Dermatopathology 61
Bullous Melanoma: should the thickness of the bullous lesion be included in Breslow depth measurement? 61
Introduction 61
Case report 62
Discussion 63
Conclusion 64
Financial support 64
Authors contributions 64
Conflicts of interest 64
References 64
Reviews 65
Effects of chemical straighteners on the hair shaft and scalp 65
Introduction 66
Methods 66
Results 66
Acid straighteners: formaldehyde, other aldehydes and formaldehyde derivatives 66
Hair relaxers 67
Straighteners in general 70
Discussion 70
Conclusion 74
Financial support 74
Authors contributions 74
Conflicts of interest 74
References 74
Sunscreen lotions in the dermatological prescription: review of concepts and controversies 76
Introduction 77
Biological effects of solar radiation on the skin 77
Photoprotection habits and dermatological practice 79
Clinical benefits of daily photoprotection 81
Advances in the formulation of sunscreens 81
Photoprotection mechanisms and amplitudes 81
Photostability 82
Antioxidants 83
DNA repairers 83
Vehicles and cosmetic texture 84
Individual safety of sunscreens 84
Environmental safety of sunscreens 86
Sunscreens and hypovitaminosis D 86
Stringency in determining the effectiveness of sunscreens 87
Regulation of sunscreens 87
Sun Protection Factor (SPF) 87
UVA Protection Factor (UVAPF) and Critical Wavelength 88
Visible light (VL) and infrared radiation (IR) 88
Assessment of water-resistance capacity 88
Photostability check 88
Sunscreen labeling 90
Final considerations 91
Financial support 91
Authors contribution 91
Conflicts of interest 92
References 92
Tropical/Infectoparasitary Dermatology 95
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients 95
Financial support 98
Authors contributions 99
Conflicts of interest 99
References 99
Epidemiological and geographical distribution profile of urban sporotrichosis in the city of So Paulo 100
Financial support 102
Authorscontributions 102
Conflicts of interest 102
References 102
Necrotic erythema nodosum reaction associated with histological alterations of Lucios phenomenon 103
Financial support 106
Authors' contributions 106
Conflicts of interest 106
References 107
Images in Dermatology 108
In vivo reflectance confocal microscopic findings in a case of trichofolliculoma 108
Case report 108
Discussion 109
Financial support 111
Authors' contributions 111
Conflicts of interest 111
References 111
Scanning electron microscopy of panitumumab-induced eyelash and hair alterations Pili canaliculi 112
Case report 113
Discussion 113
Financial support 114
Authors' contributions 114
Conflicts of interest 114
References 114
What is your Diagnosis? 115
Case for diagnosis. Erythematous-violaceous reticulated plaques on the breasts 115
Case report 115
What is your diagnosis? 115
Discussion 115
Financial support 118
Authors' contributions 118
Conflicts of interest 118
References 118
Research Letters 119
A case-control study to determine the risk factors for disability among the leprosy cases in Andhra Pradesh, India 119
Financial support 121
Authors contributions 121
Conflicts of interest 121
Acknowledgments 121
References 121
DerMohscopy: utility of dermoscopy combined with Mohs micrographic surgery for the treatment of basal cell carcinoma 122
Financial support 124
Authors contributions 124
Conflicts of interest 124
References 124
References 124
Dietary supplementation with gamma-linolenic, linoleic and oleic acids decreases PPAR-gamma expression and helps the tetracycline derivative to reduce NOD2 expression in patients with acne vulgaris 125
Financial support 127
Authors contributions 127
Conflicts of interest 127
References 127
Single-lesion paucibacillary leprosy: a retrospective study of 75 cases treated with the ROM scheme 130
Uncommon subtypes of frontal fibrosing alopecia: retrospective analysis of clinical characteristics and prognosis 132
Financial support 134
Authors contributions 134
Conflicts of interest 134
References 134
References 134
Case Letters 135
A case of multiple perforating pilomatricomas 135
Financial support 136
Authors contributions 136
Conflicts of interest 136
References 136
Acyclovir-resistant chronic mucocutaneous herpes with good response to the association with imiquimod in an AIDS patient: case report 136
Financial support 137
Authors contributions 137
Conflicts of interest 137
References 137
Bullous Sweet syndrome with a unique photodistributed pattern 138
Financial support 139
Authors' contributions 139
Conflicts of interest 139
References 139
Extraocular sebaceous carcinoma: tumor presentation of rapid evolution 140
Financial support 141
Authors contributions 141
Conflicts of interest 141
References 141
Is there a link between guttate psoriasis and SARS-CoV-2? A series of three cases 143
Financial support 144
Authors contributions 144
Conflicts of interest 144
References 144

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