Hematology, Transfusion and Cell Therapy, Vol. 43, Issue 2, April-June 2021

ABHH Rua Diogo de Faria, 775, sala 114 04037-002 São Paulo, SP, Brazil Phone/Fax: 55 11 2369-7767 www.abhh.org.br | abhh@a bhh.org.br The Hematology, Transfusion and Cell Therapy is the official publication of the Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH), the Associazione Italo-Brasiliana di Ematologia (AIBE) and the Sociedade Brasileira de Oncologia Pediátrica (SOBOPE), published by Elsevier Editora Ltda. The journal is indexed to the Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs), SciELO Brazil, PubMed/PMC, Ex- tramed and Scopus. It is distributed for free to regional libraries and Medical, Pharmacy and Biochemistry Schools in Brazil and sister societies in South, Central and North America and Europe. © 2020 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. All rights reserved and protected by law 9.610 - 19/02/98. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system, without permission in writing fromABHH and the Publisher. Editorial production by Elsevier España, SLU Avinguda Josep Tarradellas, 20-30, 1er piso 08029, Barcelona DL: B-26732-2017 No responsibility is assumed by Elsevier for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. Although all advertising material is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer. Editor in Chief Fernando Ferreira Costa – Campinas, SP, Brazil Deputy Editor Eduardo Magalhães Rego – Ribeirão Preto, Brazil Associate Editors Alfredo Mendrone Junior – São Paulo, Brazil Belinda Pinto Simões – Ribeirão Preto, Brazil Behnaz Bayat – Giessen, Germany Carlos Sérgio Chiattone – São Paulo, Brazil Cármino Antonio de Souza – Campinas, Brazil Dante Mário Langhi Junior – São Paulo, Brazil Dimas Tadeu Covas – Ribeirão Preto, Brazil Elvira Deolinda Rodrigues Pereira Velloso – São Paulo, Brazil Fabiola Traina – Ribeirão Preto, Brazil Helio Moraes de Souza – Uberaba, Brazil Irene Lorand-Metze – Campinas, Brazil José Orlando Bordin – São Paulo, Brazil Luis Fernando S. Bouzas – Rio de Janeiro, Brazil Marcelo Pasquini – Wisconsin, USA Márcio Nucci – Rio de Janeiro, Brazil Marcos Borato Viana – Belo Horizonte, Brazil Marcos de Lima – Cleveland, USA Margareth Castro Ozelo – Campinas, Brazil Maria Helena Pitombeira – Fortaleza, Brazil Maria Stella Figueiredo – São Paulo, Brazil Marilda de Souza Gonçalves – Salvador, Brazil Nelson Hamerschlak – São Paulo, Brazil Nelson Spector – Rio de Janeiro, Brazil Nicola Conran – Campinas, Brazil Paulo Sérgio da Silva Santos – São Paulo, Brazil Roberto Passetto Falcão – Ribeirão Preto, Brazil Rodrigo Tocantins Calado – Ribeirão Preto, Brazil Sara Teresinha Olalla Saad – Campinas, Brazil Silvia Maria Meira Magalhães – Fortaleza, Brazil Suely Meireles Rezende – Belo Horizonte, Brazil Valder Arruda – Philadelphia, USA Vanderson Rocha – São Paulo, Brazil Vania Tietsche de Moraes Hungria – São Paulo, Brazil HTCT Internal Editorial Committee Executive Secretary: Luciana de Souza secretaria@rbhh.org | www.htct.com.br Editorial Board Alois Gratwöhl – Basel, Switzerland Álvaro Urbano-Ispizua – Barcelona, Spain Andrea Bacigalupo – Genoa, Italy Ângelo Maiolino – Rio de Janeiro, Brazil Antonio Fabron Júnior – Marilia, Brazil Christian Gisselbrecht – Paris, France Corrado Tarella – Turin, Italy Daniel Tabak – Rio de Janeiro, Brazil David Gòmez Almaguer – Mexico City, Mexico Elbio A. D’Amico – São Paulo, Brazil Enric Carreras – Barcelona, Spain Eugenia Maria AmorimUbiali - Ribeirão Preto, Brazil Frederico Luiz Dulley – São Paulo, Brazil Gino Santini – Genoa, Italy Guillermo Dighiero – Montevideo, Uruguay Guillermo Ruiz-Arguelles – Puebla, Mexico Jesus Fernando San Miguel – Salamanca, Spain João Carlos Pina Saraiva – Belém, Brazil Laércio de Melo – Belo Horizonte, Brazil Lílian Maria Castilho – Campinas, Brazil Linamara Rizzo Batistella – São Paulo, Brazil Lucia Mariano da Rocha Silla – Porto Alegre, Brazil Marcos Antonio Zago – Ribeirão Preto, Brazil Maria de Lourdes L. F. Chauffaile – São Paulo, Brazil Maria do Socorro P. de Oliveira – Rio de Janeiro, Brazil Mario Cazolla – Pavia, Italy Mary Evelyn Flowers – Seattle, USA Nelson Abrahin Fraiji – Manaus, Brazil Nelson J. Chao – Durham, USA Paul M. Ness – Baltimore, USA Paulo César Naoum – São José do Rio Preto, Brazil Raul C. Ribeiro – Memphis, USA Raul Gabus – Montevideo, Uruguay Ricardo Pasquini – Curitiba, Brazil Richard K. Burt – Chicago, USA Sergio Giralt – New York, USA Vânia Tietsche Hungria – São Paulo, Brazil Vicente Odone Filho – São Paulo, Brazil Past Editors Antonio P. Capanema – 1973-1981; Milton A. Ruiz – 1981-1990; Carlos S. Chiattone – 1991-1994; Milton A. Ruiz – 1995-2014. The Hematology, Blood Transfusion and Cell Therapy succeeded the Revista Brasileira de Hematologia e Hemoterapia (Brazilian Journal of Hematology and Hemotherapy) , ISSN 1516-8484, which succeeded the Boletim da Sociedade Brasileira de Hematologia e Hemoterapia (Bulletin of the Brazilian Society of Hematology and Hemotherapy) ISSN 0102-7662, which was published from 1973 to 1998 with 179 issues in 20 volumes. ISSN 2531-1379 print version ISSN 2531-1387 online version Hematology, Transfusion and Cell Therapy /conjunto 133 Vila Clementino - São Paulo/SP - Brazil (11) 2369-7767 / (11) 2338-6764 (WhatsApp) E-mail: abhh@ab hh.org.br www.abhh.org.br 1