Hematology, Transfusion and Cell Therapy, Vol.44, Num.2, April - June 2022

Original Articles 1
Precursor B-lineage acute lymphoblastic leukemia patients with aberrant natural killer cell and T cell – lineage antigen e... 1
Introduction 2
Materials and methods 2
Statistics 2
Results 2
CD56+ B-ALL patients 4
CD7+ B-ALL patients 4
CD56+ B-ALL vs CD7+ B-ALL patients 5
The risk for adverse event 5
Discussion 5
Conclusion 7
Limitations 7
Conflict of interest 7
Acknowledgments 7
Appendix A Supplementary data 7
References 8
Outcome of audit and education on blood transfusion practice in obstetrics setting 9
Introduction 10
Methods 10
Results 10
Whole blood and PRBC transfusion 11
FFP and cryoprecipitate 11
Platelet concentrate 11
Discussion 11
Conclusion 13
Authors contributions 13
Conflicts of interest 13
References 13
Association of FOXO3 polymorphism (rs3800231) and clinical subphenotypes of beta thalassemic individuals 14
Introduction 15
Materials and methods 15
Subjects 15
Biological samples 15
Hemoglobin screening tests 15
Molecular analysis 15
Statistical analysis 16
Results 16
The genotypic and allelic frequency for polymorphism rs3800231 16
Association of the FOXO3 gene polymorphism with clinical manifestations 16
Discussion 16
Conclusion 18
Authorship 19
Conflicts of interest 19
Acknowledgments 19
References 19
Outpatient haploidentical hematopoietic stem cell transplant using post-transplant cyclophosphamide and incidence of hemor... 21
Introduction 22
Materials and methods 22
Patient information 22
Outpatient transplant procedure 22
Hematopoietic stem cell mobilization and collection 22
Conditioning regimen and GVHD prophylaxis 22
Statistical analysis 23
Results 23
Characteristics of patients with HC 23
Characteristics of patients without HC 24
Discussion 24
Statement of ethics 25
Conflict of interest 25
References 25
Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia 27
Introduction 28
Methods 28
Study design, setting and participants 28
Eligibility criteria 28
Ethical review 28
Measurements 28
Data collection instruments 28
Laboratory methods 29
Statistical analysis 29
Results 29
Participant description 29
LU profile in participants with SCA 30
Association of LUs with laboratory data 30
Discussion 30
Funding 34
Conflicts of interest 34
Acknowledgments 34
References 34
Sickle cell disease related mortality in Brazil, 2000–2018 35
Introduction 35
Methods 36
Results 37
Discussion 38
Conflicts of interest 42
References 42
Bibliometric analysis of global sickle cell disease research from 1997 to 2017 44
Introduction 45
Methods 45
Data source 45
Bibliometric indicators 45
Results 46
Assessment of global publication 46
Analysis of sources with highest publication 47
Productivity of Institutions 48
Productivity of authors 49
Citation analysis of articles 49
Keyword analysis 49
Discussion 49
Conclusion 53
Author contributions 53
Conflicts of interest 53
References 53
Optimizing the recovery of peripheral blood mononuclear cells trapped in leukoreduction filters - A comparison study 55
Introduction 56
Materials and methods 56
Reagents and antibodies 56
Isolation of cells from leukoflex filters 56
Blood cell counting 57
Yield of isolation 57
Viability assay 58
Isolation of MNCs 58
Characterization of mononuclear stem cells (MNSCs) 58
Data analysis 58
Results 58
Effect of applied methods on the rate of isolation 58
Effect of cell isolation methods on the viability of MNCs 59
The characterization results of cells derived from LRFs 59
Morphology evaluation of MNCs 59
Discussion 61
Conclusion 62
Funding 62
Conflicts of interest 62
Acknowledgment 62
Supplementary Material for Reviews section 62
References 62
Development and implementation of a COVID-19 convalescent plasma program in a middle-income economy 65
Introduction 65
Methods 65
Donor recruitment and eligibility 65
Inclusion criteria 65
Antibody screening 65
Plasma collection and production 66
Statistical analysis 66
Results 66
Convalescent plasma distribution 67
Discussion 67
Conclusion 69
Conflicts of interest 69
Acknowledgments 69
References 69
Association between FY*02N.01 and the severity of COVID-19: initial observations 65
Introduction 65
Methods 72
Patient recruitment 72
DNA extraction 72
Genotyping of ACKR1 c.-67T≥C 72
Statistical analysis 72
Results 72
Characteristics of the COVID-19 patients 72
Duffy null genotype 73
Discussion 73
Conclusion 74
Conflicts of interest 74
Acknowledgements 74
REFERENCES 74
Hematological changes in SARS-COV-2 positive patients 77
Introduction 77
Objectives 77
Methods 77
Results 78
Discussion 81
Conclusions 82
Conflicts of interest 82
Acknowledgments 82
References 82
Review Articles 156
Proportion of hematological cancer patients with SARS-CoV-2 infection during the COVID-19 pandemic: A systematic review and meta-analysis 156
Introduction 156
Method 84
Identification of relevant studies 84
Inclusion and exclusion criteria 84
Data extraction 84
Quality assessment 85
Data synthesis 85
Results 87
Characteristics of eligible studies 87
Quantitative data synthesis 88
Heterogeneity test 88
Sensitivity analysis 89
Publication bias 89
Discussion 90
Conclusion 91
Conflicts of interest 91
Acknowledgements 91
References 91
Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 94
Introduction 94
SARS-COV-2 infection from molecular Standpoint 162
Hematological implications of Sars-Cov-2 infection: pathophysiological erythrocytic protagonism 95
Clinical exam and proteomics: perspectives 98
Conclusion 72
Funding 100
Conflicts of interest 100
Acknowledgments 100
References 100
Special Article 104
Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular guidelines project: Associação Médica Brasileira - 2022 104
Introduction 104
Description of the method used to collect evidence 105
Background 105
Clinical questions 72
Conflicts of interest 110
Appendix 110
References 111
Case Reports 114
Clopidogrel-induced neutropenia in a 84-year-old patient: A case report 114
Introduction 114
Case report 114
Discussion 115
References 116
Oral mucosa infection by Mycoplasma salivarium in a patient with chronic graft-versus-host disease: a diagnostic challenge 117
Introduction 117
Case report 118
Discussion 120
Conflict of interest 120
Acknowledgments 120
References 120
Megakaryocytic blast crisis in chronic myeloid leukiemia: An uncommon presentation in a common neoplasm 122
Introduction 122
Case report 122
Discussion 125
Conclusion 125
Conflicts of interest 125
References 126
Hereditary thrombotic thrombocytopenic purpura: a case report 127
Introduction 127
Case report 127
Discussion 128
Conclusion 129
Conflicts of interest 129
References 129
Non-RhD (anti-E) red cell alloimmunization following platelet transfusion: a case report and implications on quality of th... 130
Introduction 130
Case report 130
Discussion 131
References 132
Primary pediatric Burkitt’s lymphoma of both femurs—case report 133
Introduction 133
Clinical case 133
Discussion 135
Conflicts of interest 135
References 135
Peripheral lymphocytosis presenting as EBV/HTLV-1 co-infection adult T-cell leukemia 137
Introduction 137
Case presentation 137
Discussion 138
Conclusion 140
Author contributions 140
Conflicts of interest 141
References 141
Bradycardia associated with antithymocyte globulin treatment of a pediatric patient with sickle cell disease: a case repor... 142
Introduction 142
Case report 142
Discussion 143
Conclusion 144
Conflict of interest 144
References 144
Anti-M antibody and ABO blood grouping discrepancy: a report of three cases with review of literature 146
Introduction 146
Case 1 146
Case 2 147
Case 3 147
Discussion 147
Conclusion 148
Conflicts of interest 148
References 148
COVID-19 induced follicular lymphoma remission 149
Introduction 149
Case report 77
Comments 150
Conflicts of interest 78
References 150
Letters to the Editor 94
Vaccine responses in patients with chronic lymphocytic leukemia on treatment with Bruton Tyrosine Kinase Inhibitors: a focused review 94
Conflicts of interest 94
References 153
Transfusion related acute lung injury: a rare case after single Packed Red Blood Cell unit transfusion 156
Conflicts of interest 156
References 156
Prolonged viral shedding of SARS-CoV-2 in patients with acute leukemia 104
Conflicts of interest 104
References 158
Images in Clinical Hematology 160
Reed-Sternberg and Hodgkin cells in bone marrow aspirate from a classical Hodgkin lymphoma patient 160
Conflicts of interest 160
References 65
Megakaryocytes in pulmonary circulation: an 162
Conflicts of interest 162
References 162

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