256. Chan KH, Dearden NM, Miller JD, et al: Multimo-
dality monitoring as a guide to treatment of intra-
cranial hypertension after severe brain injury.
Neurosurgery 32:547–553, 1993.
257. Robertson CS, Valadka AB, Hannay HJ, et al: Pre-
vention of secondary ischemic insults after severe
head injury. Crit Care Med 27:2086–2095, 1999.
258. Bruzzone P, Dionigi R, Bellinzona G, et al: Effects of
cerebral perfusion pressure on brain tissue PO
2
in
patients with severe head injury. Acta Neurochir
71:111–113, 1998.
259. Marshall LF: Head injury: Recent past, present and
future [editorial]. Neurosurgery 47:546–561, 2000.
260. Robertson CS: Management of cerebral perfusion
pressure after traumatic brain injury. Anesthesio-
logy 95:1513–1517, 2001.
261. Stiefel MF, Udoetuk JD, Spiotta AM, et al: Conven-
tional neurocritical care and cerebral oxygenation
after traumatic brain injury. J Neurosurg 105:568–
575, 2006.
262. Rosner MJ, Rosner SD, Johnson AH: Cerebral per-
fusion pressure: Management protocol and clinical
results. J Neurosurg 83:949–962, 1995.
263. Czosnyka M, Smielewski P, Piechnik S, et al: Cere-
bral autoregulation following head injury. J Neuro-
surg 95:756–763, 2001.
264. Asgeirsson B, Grande PO, Nordstrom CH: A new
therapy of post-trauma brain oedema based on
haemodynamic principles for brain volume regula-
tion. Intensive Care Med 20:260–267, 1994.
265. Asgeirsson B, Grande PO, Nordstrom CH: The
Lund concept of post-traumatic brain oedema
therapy. Acta Anaesthesiol Scand 39:103–106,
1995.
266. Grande PO, Asgeirsson B, Nordstrom CH: Volume-
targeted therapy of increased intracranial pressure:
The Lund concept unifies surgical and non-surgical
treatments. Acta Anaesthesiol Scand 46:929–941,
2002.
267. Naredi S, Eden E, Zall S, et al: A standardized neu-
rosurgical/neurointensive therapy directed toward
vasogenic edema after severe traumatic brain
injury: Clinical results. Intensive Care Med 24:446–
451, 1998.
268. Eker C, Asgeirsson B, Grande P-O, et al: Improved
outcome after severe head injury with a new therapy
based on principles for brain volume regulation and
preserved microcirculation. Crit Care Med
26:1881–1886, 1998.
269. Naredi S, Olivecrona M, Lindgren C, et al: An
outcome study of severe traumatic head injury
using the “Lund therapy” with low-dose prostacy-
clin. Acta Anaesthesiol Scand 45:402–406, 2001.
270. Steiger HJ, Ciessinna E, Seiler RW: Identification of
posttraumatic ischemia and hyperfusion by deter-
mination of effect of induced arterial hypertension
on carbon dioxide reactivity. Stroke 27:2048–2051,
1996.
271. Romner B, Bellner J, Kongstad P, et al: Elevated
transcranial Doppler flow velocities after severe
head injury: Cerebral vasospasm or hyperemia?
J Neurosurg 85:90–97, 1996.
272. Steiner LA, Johnston AJ, Czosnyka M, et al: Direct
comparison of cerebrovascular effects of norepi-
nephrine and dopamine in head-injured patients.
Crit Care Med 32:1049–1054, 2004.
273. Kelly DF, Kordestani RK, Martin NA, et al: Hypere-
mia following traumatic brain injury: Relationship
to intracranial hypertension and outcome. J Neuro-
surg 85:762–771, 1996.
274. Muizelaar JP, Marmarou A, DeSalles AAF, et al:
Cerebral blood flow and metabolism in severely
head-injured children, part 1: Relationship with
GCS score, outcome, ICP, and PVI. J Neurosurg
71:63–71, 1989.
275. Warner DS, Borel CO: Treatment of traumatic brain
injury: One size does not fit all. Anesth Analg
99:1208–1210, 2004.
276. Coles JP, Steiner LA, Johnston AJ, et al: Does
induced hypertension reduce cerebral ischaemia
within the traumatized human brain? Brain
127:2479–2490, 2004.
277. Cremer OL, van Dijk GW, Amelink GJ, et al: Cere-
bral hemodynamic responses to blood pressure
manipulation in severely head-injured patients in
the presence or absence of intracranial hyperten-
sion. Anesth Analg 99:1211–1217, 2004.
278. Hlatky R, Valadka AB, Robertson CS: Intracranial
pressure response to induced hypertension: Role of
dynamic pressure autoregulation. Neurosurgery
57:917–923, 2005.
279. Bouma GJ, Muizelaar JP, Bandoh K, et al: Blood
pressure and intracranial pressure-volume dyna-
mics in severe head injury: Relationship with cere-
bral blood flow. J Neurosurg 77:15–19, 1992.
280. Juul N, Morris GF, Marshall SB, et al: Intracranial
hypertension and cerebral perfusion pressure: Their
influence on neurological deterioration and outcome
in severe head injury. J Neurosurg 92:1–6, 2000.
281. Clayton TJ, Nelson RJ, Manara AR: Reduction in
mortality from severe head injury following intro-
duction of a protocol for intensive care manage-
ment. Br J Anaesth 93:761–767, 2004.
282. Chambers IR, Treadwell L, Mendelow AD: Deter-
mination of threshold levels of cerebral perfusion
pressure and intracranial pressure in severe head
injury by using receiver-operating characteristic
curves: An observational study in 291 patients. J
Neurosurg 94:412, 2001.
283. Stocchetti N, Maas AI, Chieregato A, et al: Hyper-
ventilation in head injury: A review. Chest
127:1812–1827, 2005.
284. Nekludov M, Antovic J, Bredbacka S, et al: Coagu-
lation abnormalities associated with severe isolated
traumatic brain injury: Cerebral arterio-venous
differences in coagulation and inflammatory
markers. J Neurotrauma 24:174–180, 2007.
285. White H, Baker A: Continuous jugular venous
oximetry in the neurointensive care unit—a brief
review. Can J Anesth 49:623–629, 2002.
286. Stocchetti N, Paparella A, Bridelli F, et al: Cerebral
venous oxygen saturation studied with bilateral
samples in the internal jugular veins. Neurosurgery
34:38, 1994.
287. Schneider GH, Helden AV, Lanksch WR, et al: Con-
tinuous monitoring of jugular bulb oxygen satura-
tionincomatosepatients—therapeuticimplications.
Acta Neurochir 134:71–75, 1995.
288. Gopinath SP, Cormio M, Ziegler J, et al: Intraopera-
tive jugular desaturation during surgery for trauma-
tic intracranial hematomas. Anesth Analg
83:1014–1021, 1996.
289. Nortje J, Gupta AK: The role of tissue oxygen moni-
toring in patients with acute brain injury. Br J
Anaesth 97:95–106, 2006.
290. Stiefel MF, Spiotta A, Gracias VH, et al: Reduced
mortality rate in patients with severe traumatic
brain injury treated with brain tissue oxygen moni-
toring. J Neurosurg 103:805–811, 2005.
291. Marshall LF, Toole BM, Bowers SA: The National
Traumatic Coma Data Bank, part 2: Patients who
talk and deteriorate: Implications for treatment. J
Neurosurg 59:285–288, 1983.
292. Drummond JC, Todd MM: Acute sinus arrhythmia
during surgery in the fourth ventricle: An indicator
of brain-stem irritation. Anesthesiology 60:232–
236, 1984.
293. Lobato RD, Rivas JJ, Sarabia R, et al: Percutaneous
microcompression of the gasserian ganglion for tri-
geminal neuralgia. J Neurosurg 72:546–553, 1990.
294. Skirving DJ, Dan NG: A 20-year review of percuta-
neous balloon compression of the trigeminal gan-
glion. J Neurosurg 94:913, 2001.
295. Manninen PH, Cuillerier DJ, Nantau WE, et al:
Monitoring of brainstem function during vertebral
basilar aneurysm surgery: The use of spontaneous
ventilation. Anesthesiology 77:681–685, 1992.
296. Nemergut EC, Dumont AS, Barry UT, et al: Perio-
perative management of patients undergoing trans-
sphenoidal pituitary surgery. Anesth Analg 101:
1170–1181, 2005.
297. Korula G, George SP, Rajshekhar V, et al: Effect of
controlled hypercapnia on cerebrospinal fluid pres-
sure and operating conditions during transsphenoi-
dal operations for pituitary macroadenoma. J
Neurosurg Anesthesiol 13:255–259, 2001.
298. Nath G, Korula G, Chandy MJ: Effect of intrathecal
saline injection and Valsalva maneuver on cerebral
perfusion pressure during transsphenoidal surgery
for pituitary macroadenoma. J Neurosurg Anes-
thesiol 7:1–6, 1995.
299. Spaziante R, DeDivitiis E: Forced subarachnoid air in
transsphenoidalexcisionofpituitarytumors(pumping
technique). J Neurosurg 71:864–867, 1989.
300. Drummond JC, Iragui-Madoz VJ, Alksne JF, et al:
Masking of epileptiform activity by propofol during
seizure surgery. Anesthesiology 76:652–654, 1992.
301. Herrick IA, Craen RA, Gelb AW, et al: Propofol
sedation during awake craniotomy for seizures:
Patient-controlled administration versus neurolept
analgesia. Anesth Analg 84:1280–1284, 1997.
302. Manninen PH, Balki M, Lukitto K, et al: Patient
satisfaction with awake craniotomy for tumor
surgery: A comparison of remifentanil and fentanyl
in conjunction with propofol. Anesth Analg
102:237–242, 2006.
303. Keifer JC, Dentchev D, Little K, et al: A retrospective
analysis of a remifentanil/propofol general anes-
thetic for craniotomy before awake functional brain
mapping. Anesth Analg 101:502–508, 2005.
304. Mack PF, Perrine K, Kobylarz E, et al: Dexmedeto-
midine and neurocognitive testing in awake cranio-
tomy. J Neurosurg Anesthesiol 16:20–25, 2004.
305. Ard J, Doyle W, Bekker A: Awake craniotomy with
dexmedetomidine in pediatric patients. J Neurosurg
Anesthesiol 15:263–266, 2003.
306. Bekker AY, Kaufman B, Samir H, et al: The use of
dexmedetomidine infusion for awake craniotomy.
Anesth Analg 92:1251–1253, 2001.
307. Souter MJ, Rozet I, Ojemann JG, et al: Dexmedeto-
midine sedation during awake craniotomy for
seizure resection: Effects on electrocorticography.
J Neurosurg Anesthesiol 19:38–44, 2007.
308. Talke P, Stapelfeldt C, Garcia P: Dexmedetomidine
does not reduce epileptiform discharges in adults
with epilepsy. J Neurosurg Anesthesiol 19:195–199,
2007.
309. Bustillo MA, Lazar RM, Finck AD, et al: Dexmede-
tomidine may impair cognitive testing during
endovascular embolization of cerebral arteriove-
nous malformations: A retrospective case report
series. J Neurosurg Anesthesiol 14:209–212, 2002.
310. Sarang A, Dinsmore J: Anaesthesia for awake cra-
niotomy—evolution of a technique that facilitates
awake neurological testing. Br J Anaesth 90:161–
165, 2003.
311. Cascino GD: Pharmacological activation. Electro-
encephalogr Clin Neurophysiol Suppl 48:70–76,
1998.
312. Cascino GD, So EL, Sharbrough FW, et al: Alfenta-
nil-induced epileptiform activity in patients with
partial epilepsy. J Clin Neurophysiol 10:520–525,
1993.
313. McGuire G, El-Beheiry H, Manninen P, et al: Acti-
vation of electrocorticographic activity with remi-
fentanilandalfentanilduringneurosurgicalexcision
of epileptogenic focus. Br J Anaesth 91:651–655,
2003.
314. Ebrahim ZY, DeBoer GE, Luders H, et al: Effect of
etomidate on the electroencephalogram of patients
with epilepsy. Anesth Analg 65:1004–1006, 1986.
315. Gancher S, Laxer KD, Krieger W: Activation of
epileptogenic activity by etomidate. Anesthesiology
61:616–618, 1984.
316. Wass CT, Grady RE, Fessler AJ, et al: The effects of
remifentanil on epileptiform discharges during
intraoperative
electrocorticography.
Epilepsia
42:1340–1344, 2001.
317. Perlmutter JS, Mink JW: Deep brain stimulation.
Annu Rev Neurosci 29:229–257, 2006.
318. Hammond C, Bergman H, Brown P: Pathological
synchronization in Parkinson’s disease: Networks,
models and treatments. Trends Neurosci 30:357–
364, 2007.
319. Rozet I, Muangman S, Vavilala MS, et al: Clinical
experience with dexmedetomidine for implantation
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