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pacientes sometidos a cirugía vascular. En un ensayo aleatorizado

prospectivo, el riesgo relativo de morbilidad cardíaca en el período

postoperatorio inmediato se redujo un 55% cuando se mantuvo la

normotermia con sistemas de calentamiento mediante aire for­

zad

o 165

. En el postoperatorio inmediato, los pacientes sometidos

a cirugía vascular muestran el doble o el triple de incidencia de

isquemia miocárdica cuando la temperatura central es inferior a

35 °

C 166 .

Incluso una hipotermia leve de unos 35 °C se asocia a un

incremento del 200-700% de las concentraciones de norepin-

efrin

a 163,506

, vasoconstricción generalizad

a 507

y elevación de la

presión arterial en el postoperatori

o 163 .

Los escalofríos son habitua-

les y aumentan el consumo de oxígeno corporal total, pero sólo en

un 40% en el paciente vascular anciano típic

o 152 .

Es importante controlar la respuesta al estrés en el postope-

ratorio. Esto incluye la prevención de posibles factores desenca­

denantes de isquemia miocárdica (dolor, anemia, hipotermia,

extremos hemodinámicos e insuficiencia ventilatoria). En los

pacientes sometidos a ventilación mecánica, el período de destete

resulta especialmente estresante y es frecuente que se produzca

isquemia miocárdica durante el mism

o 508 .

Lo deseable sería sedar

cuidadosamente al paciente y destetarlo con rapidez. Cuando sea

posible, la extubación dentro del quirófano resulta menos estre-

sante y es preferible para los pacientes sometidos a cirugía vascular

carotídea o de la extremidad inferior. Cuando la cirugía es más

cruenta (AAT o aneurismas de aorta abdominal), suele ser precisa

una ventilación mecánica postoperatoria.

La cirugía vascular sigue representando un reto para el anes-

tesista dado el notable estrés fisiológico que se produce en una pobla-

ciónrelativamenteancianaconunaelevadaincidenciadeenfermedades

concomitantes. Los estudios clínicos proporcionan una perspectiva

sobre la valoración preoperatoria y la optimización del riesgo car-

díaco, las implicaciones de la técnica anestésica y el diagnóstico, pre-

vención y tratamiento de la isquemia miocárdica en pacientes que

van a someterse a cirugía vascular. Estos estudios han mejorado

nuestra capacidad de tratamiento de los pacientes de cirugía vascular,

reduciendo la morbilidad y mejorando el pronóstico global.

Bibliografía

1. Stary HC, Chandler AB, Dinsmore RE, et al: A defi-

nition of advanced types of atherosclerotic lesions

and a histological classification of atherosclerosis.

A report from the Committee on Vascular Lesions

of the Council on Arteriosclerosis, American Heart

Association. Arterioscler Thromb Vasc Biol 15:

1512-1531, 1995.

2. Stary HC: Natural history and histological classifi-

cation of atherosclerotic lesions: An update. Arte-

rioscler Thromb Vasc Biol 20:1177-1178, 2000.

3. Ross R: Atherosclerosis—an inflammatory disease.

N Engl J Med 340:115-126, 1999.

4. Libby P, Ridker PM, Maseri A: Inflammation and

atherosclerosis. Circulation 105:1135-1143, 2002.

5. Aikawa M, Rabkin E, Sugiyama S, et al: An

HMG-CoA reductase inhibitor, cerivastatin,

suppresses growth of macrophages expressing

matrix metalloproteinases and tissue factor in vivo

and in vitro. Circulation 103:276-283, 2001.

6. Ridker PM: High-sensitivity C-reactive protein:

Potential adjunct for global risk assessment in the

primary prevention of cardiovascular disease. Cir-

culation 103:1813-1818, 2001.

7. Horowitz GL, Beckwith BA: C-reactive protein in

the prediction of cardiovascular disease. N Engl J

Med 343:512-513, 2000.

8. Liuzzo G, Biasucci LM, Gallimore JR, et al: The

prognostic value of C-reactive protein and serum

amyloid a protein in severe unstable angina. N Engl

J Med 331:417-424, 1994.

9. Ridker PM, Cushman M, Stampfer MJ, et al: Plasma

concentration of C-reactive protein and risk of

developing peripheral vascular disease. Circulation

97:425-428, 1998.

10. Murray WM: Inflammation, aspirin, and the risk of

cardiovascular disease. N Engl J Med 337:422, 1997,

author reply 423-424.

11. LaRosa JC, Hunninghake D, Bush D, et al: The cho-

lesterol facts. A summary of the evidence relating

dietary fats, serum cholesterol, and coronary heart

disease. A joint statement by the American Heart

Association and the National Heart, Lung, and

Blood Institute. The Task Force on Cholesterol

Issues, American Heart Association. Circulation

81:1721-1733, 1990.

12. Shepherd J, Cobbe SM, Ford I, et al: Prevention of

coronary heart disease with pravastatin in men with

hypercholesterolemia. West of Scotland Coronary

Prevention Study Group. N Engl J Med 333:1301-

1307, 1995.

13. Prevention of cardiovascular events and death with

pravastatin in patients with coronary heart disease

and a broad range of initial cholesterol levels. The

Long-Term Intervention with Pravastatin in Ischae-

mic Disease (LIPID) Study Group. N Engl J Med

339:1349-1357, 1998.

14. MRC/BHF Heart Protection Study of cholesterol

lowering with simvastatin in 20,536 high-risk indi-

viduals: A randomised placebo-controlled trial.

Lancet 360:7-22, 2002.

15. Small DM: George Lyman Duff memorial lecture.

Progression and regression of atherosclerotic

lesions. Insights from lipid physical biochemistry.

Arteriosclerosis 8:103-129, 1988.

16. Salonen RM, Nyyssonen K, Kaikkonen J, et al: Six-

year effect of combined vitamin C and E supple-

mentation on atherosclerotic progression: The

Antioxidant Supplementation in Atherosclerosis

Prevention (ASAP) Study. Circulation 107:947-953,

2003.

17. Mangano DT: Perioperative cardiac morbidity.

Anesthesiology 72:153-184, 1990.

18. Feringa HH, Karagiannis SE, Vidakovic R, et al: The

prevalence and prognosis of unrecognized myocar-

dial infarction and silent myocardial ischemia in

patients undergoing major vascular surgery. Coron

Artery Dis 18:571-576, 2007.

19. Kelly R, Staines A, MacWalter R, et al: The preva-

lence of treatable left ventricular systolic dys-

function in patients who present with noncardiac

vascular episodes: A case-control study. J Am Coll

Cardiol 39:219-224, 2002.

20. Hertzer NR, Beven EG, Young JR, et al: Coronary

artery disease in peripheral vascular patients. A

classification of 1000 coronary angiograms and

results of surgical management. Ann Surg 199:223-

233, 1984.

21. Krupski WC, Layug EL, Reilly LM, et al: Compari-

son of cardiac morbidity between aortic and infra-

inguinal operations. Study of Perioperative Ischemia

(SPI) Research Group. J Vasc Surg 15:354-363, 1992,

discussion 364-365.

22. Krupski WC, Layug EL, Reilly LM, et al: Compari-

son of cardiac morbidity rates between aortic and

infrainguinal operations: Two-year follow-up. Study

of Perioperative Ischemia Research Group. J Vasc

Surg 18:609-615, 1993, discussion 615-617.

23. Fleisher LA, Nelson AH, Rosenbaum SH: Failure of

negative dipyridamole thallium scans to predict

perioperative myocardial ischaemia and infarction.

Can J Anaesth 39:179-183, 1992.

24. Ouyang P, Gerstenblith G, Furman WR, et al: Fre-

quency and significance of early postoperative

silent myocardial ischemia in patients having peri-

pheral vascular surgery. Am J Cardiol 64:1113-1136,

1989.

25. Raby KE, Goldman L, Cook EF, et al: Long-term

prognosis of myocardial ischemia detected by

Holter monitoring in peripheral vascular disease.

Am J Cardiol 66:1309-1313, 1990.

26. Mangano DT, Browner WS, Hollenberg M, et al:

Association of perioperative myocardial ischemia

with cardiac morbidity and mortality in men

undergoing noncardiac surgery. The Study of Perio-

perative Ischemia Research Group. N Engl J Med

323:1781-1788, 1990.

27. Bode RH Jr, Lewis KP, Zarich SW, et al: Cardiac

outcome after peripheral vascular surgery. Compa-

rison of general and regional anesthesia. Anesthe-

siology 84:3-13, 1996.

28. Christopherson R, Beattie C, Frank SM, et al: Perio-

perative morbidity in patients randomized to epi-

dural or general anesthesia for lower extremity

vascular surgery. Perioperative Ischemia Randomi-

zed Anesthesia Trial Study Group. Anesthesiology

79:422-434, 1993.

29. Mangano DT, London MJ, Tubau JF, et al: Dipyrida-

mole thallium-201 scintigraphy as a preoperative

screening test. A reexamination of its predictive

potential. Study of Perioperative Ischemia Research

Group. Circulation 84:493-502, 1991.

30. Fleisher LA, Rosenbaum SH, Nelson AH, Barash

PG: The predictive value of preoperative silent

ischemia for postoperative ischemic cardiac events

in vascular and nonvascular surgery patients. Am

Heart J 122:980-986, 1991.

31. Pasternak PE, Grossi EA, Baumann FG, et al: The

value of silent myocardial ischemia monitoring in

the prediction of preioperative myocardial infarc-

tion in patients undergoing peripheral vascular

surgery. J Vasc Surg 10:617-625, 1989.

Anestesia para la cirugía vascular

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52

Sección IV

Anestesia por subespecialidades en el adulto

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