67. Kelz MB, Sun Y, Chen J, et al: An essential role for
orexins in emergence from general anesthesia. Proc
Natl Acad Sci USA 105:1309, 2008.
68. Nelson LE, Lu J, Guo T, et al: The alpha2-adrenocep-
tor agonist dexmedetomidine converges on an
endogenous sleep-promoting pathway to exert its
sedative effects. Anesthesiology 98:428, 2003.
69. Miller RD, Way WL, Eger EI 2nd: The effects of
alpha-methyldopa, reserpine, guanethidine, and
iproniazid on minimum alveolar anesthetic require-
ment (MAC). Anesthesiology 29:1153, 1968.
70. Johnston RR, Way WL, Miller RD: Alteration of
anesthetic requirement by amphetamine. Anesthe-
siology 36:357, 1972.
71. Mueller RA, Smith RD, Spruill WA, et al: Central
monaminergic neuronal effects on minimum alveo-
lar concentrations (MAC) of halothane and cyclo-
propane in rats. Anesthesiology 42:143, 1975.
72. Roizen MF, White PF, Eger EI 2nd, et al: Effects of
ablation of serotonin or norepinephrine brain-stem
areas on halothane and cyclopropane MACs in rats.
Anesthesiology 49:252, 1978.
73. Sukhotinsky I, Hopkins DA, Lu J, et al: Move-
ment suppression during anesthesia: Neural
projections from the mesopontine tegmentum
to areas involved in motor control. J Comp
Neurol 489:425, 2005.
74. Sukhotinsky I,ZalkindV,Lu J,et al: Neural pathways
associated with loss of consciousness caused by
intracerebral microinjection of GABA(A)-active
anesthetics. Eur J Neurosci 25:1417, 2007.
75. Ma J, Shen B, Stewart LS, et al: The septohippocam-
pal system participates in general anesthesia. J Neu-
rosci 22:RC200, 2002.
76. Milner B, Squire LR, Kandel ER: Cognitive neuros-
cience and the study of memory. Neuron 20:445,
1998.
77. Zalta EN. Stanford Encyclopedia of Philosophy.
Available at
http://plato.stanford.edu .78. Squire LR, Kandel ER: Memory: From Mind to
Molecules. New York, Owl Books, 2000.
79. Cajal SR: The croonian lecture: La fine structure des
centres nerveux. Proc R Soc Lond 5:444–468, 1894.
80. Pavlov IP, Anrep GV II: Conditioned Reflexes; an
Investigation of the Physiological Activity of the
Cerebral Cortex. London, Oxford University Press,
Humphrey Milford, 1927.
81. Lashley KS: Basic neural mechanisms in behavior.
Psychol Rev 37:1, 1930.
82. Corkin S, Amaral DG, Gonzalez RG, et al: H.M. ‘s
medial temporal lobe lesion: Findings from magne-
tic resonance imaging. J Neurosci 17:3964, 1997.
83. Squire LR: Memory and the hippocampus: A syn-
thesis from findings with rats, monkeys, and
humans. Psychol Rev 99:195, 1992.
84. Jackson JH. Selected writings of John Hughlings
Jackson, vol I and II. London, Hodder, 1931-1932.
85. Ribot T: Diseases of Memory. New York, Appleton,
1882.
86. Frankland PW, Bontempi B: The organization of
recent and remote memories. Nat Rev Neurosci
6:119, 2005.
87. Rempel-Clower NL, Zola SM, Squire LR, et al: Three
cases of enduring memory impairment after bilate-
ral damage limited to the hippocampal formation. J
Neurosci 16:5233, 1996.
88. Squire LR: Memory systems of the brain: A brief
history and current perspective. Neurobiol Learn
Mem 82:171, 2004.
89. Squire LR, Zola SM: Structure and function of
declarative and nondeclarative memory systems.
Proc Natl Acad Sci USA 93:13515, 1996.
90. Hassabis D,Kumaran D,Vann SD,et al: Patients with
hippocampal amnesia cannot imagine new expe-
riences. Proc Natl Acad Sci USA 104:1726, 2007.
91. Bechara A, Tranel D, Damasio H, et al: Double dis-
sociation of conditioning and declarative knowledge
relative to the amygdala and hippocampus in
humans. Science 269:1115, 1995.
92. Lechner HA, Squire LR, Byrne JH: 100 years of
consolidation—remembering Muller and Pilzecker.
Learn Mem 6:77, 1999.
93. McGaugh JL: Memory—a century of consolidation.
Science 287:248, 2000.
94. Duncan CP: The retroactive effect of electroshock
on learning. J Comp Physiol Psychol 42:32, 1949.
95. Gerard RW: Physiology and psychiatry. Am J Psy-
chiatry 106:161, 1949.
96. Hebb DO: The Organization of Behavior. New York,
John Wiley & Sons, 1949.
97. Davis HP,Squire LR: Protein synthesis and memory:
A review. Psychol Bull 96:518, 1984.
98. Bliss TV, Collingridge GL: A synaptic model of
memory: Long-term potentiation in the hippocam-
pus. Nature 361:31, 1993.
99. Martin SJ, Grimwood PD, Morris RG: Synaptic plas-
ticity and memory: An evaluation of the hypothesis.
Annu Rev Neurosci 23:649, 2000.
100. Moser EI, Krobert KA, Moser MB, et al: Impaired
spatial learning after saturation of long-term poten-
tiation. Science 281:2038, 1998.
101. Whitlock JR, Heynen AJ, Shuler MG, et al: Learning
induces long-term potentiation in the hippocam-
pus. Science 313:1093, 2006.
102. Malenka RC, Nicoll RA: Long-term potentiation—a
decade of progress? Science 285:1870, 1999.
103. McClung CA, Nestler EJ: Neuroplasticity mediated
by altered gene expression.Neuropsychopharmaco-
logy 33:3, 2008.
104. Reymann KG, Frey JU: The late maintenance of
hippocampal LTP: Requirements, phases, “synaptic
tagging,” “late-associativity” and implications. Neu-
ropharmacology 52:24, 2007.
105. Levenson JM, Sweatt JD: Epigenetic mechanisms
in memory formation. Nat Rev Neurosci 6:108,
2005.
106. Malinow R,Malenka RC:AMPA receptor trafficking
and synaptic plasticity. Annu Rev Neurosci 25:103,
2002.
107. Nayak A, Zastrow DJ, Lickteig R, et al: Maintenance
of late-phase LTP is accompanied by PKA-depen-
dent increase in AMPA receptor synthesis. Nature
394:680, 1998.
108. Veselis RA: Memory: A guide for anaesthetists. Best
Pract Res Clin Anaesthesiol 21:297, 2007.
109. Dwyer R, Bennett HL, Eger EI 2nd, et al: Effects of
isoflurane and nitrous oxide in subanesthetic con-
centrations on memory and responsiveness in
volunteers. Anesthesiology 77:888, 1992.
110. Dutton RC, Maurer AJ, Sonner JM, et al: The con-
centration of isoflurane required to suppress lear-
ningdependsonthetypeof learning.Anesthesiology
94:514, 2001.
111. Alkire MT, Gorski LA: Relative amnesic potency of
five inhalational anesthetics follows the Meyer-
Overton rule. Anesthesiology 101:417, 2004.
112. Simon W, Hapfelmeier G, Kochs E, et al: Isoflurane
blocks synaptic plasticity in the mouse hippocam-
pus. Anesthesiology 94:1058, 2001.
113. Akhondzadeh S, Stone TW: Potentiation of musci-
mol-induced long-term depression by benzodiaze-
pines and prevention or reversal by pregnenolone
sulfate. Pharmacol Res 38:441, 1998.
114. Nagashima K, Zorumski CF, Izumi Y: Propofol inhi-
bits long-term potentiation but not long-term
depression in rat hippocampal slices. Anesthesio-
logy 103:318, 2005.
115. Takamatsu I, Sekiguchi M, Wada K, et al: Propofol-
mediated impairment of CA1 long-term potentia-
tion in mouse hippocampal slices. Neurosci Lett
389:129, 2005.
116. CaraiscosVB,Newell JG,You-Ten KE,et al: Selective
enhancement of tonic GABAergic inhibition in
murine hippocampal neurons by low concentra-
tions of the volatile anesthetic isoflurane. J Neurosci
24:8454, 2004.
117. Fibuch EE, Wang JQ: Inhibition of the MAPK/ERK
cascade: A potential transcription-dependent
mechanism for the amnesic effect of anesthetic pro-
pofol. Neurosci Bull 23:119, 2007.
118. Gerlai R, McNamara A: Anesthesia induced retro-
grade amnesia is ameliorated by ephrinA5-IgG in
mice: EphA receptor tyrosine kinases are involved in
mammalian memory. Behav Brain Res 108:133,
2000.
119. Kozinn J, Mao L, Arora A, et al: Inhibition of glu-
tamatergic activation of extracellular signal–regu-
lated protein kinases in hippocampal neurons by
the intravenous anesthetic propofol. Anesthesio-
logy 105:1182, 2006.
120. Perouansky M, Hentschke H, Perkins M, et al:
Amnesic concentrations of the nonimmobilizer 1,2-
dichlorohexafluorocyclobutane (F6, 2N) and isoflu-
rane alter hippocampal theta oscillations in vivo.
Anesthesiology 106:1168, 2007.
121. Alkire MT, Nathan SV: Does the amygdala mediate
anesthetic-induced amnesia? Basolateral amygdala
lesions block sevoflurane-induced amnesia. Anes-
thesiology 102:754, 2005.
122. Alkire MT, Vazdarjanova A, Dickinson-Anson H,
et al: Lesions of the basolateral amygdala complex
block propofol-induced amnesia for inhibitory avoi-
dance learning in rats. Anesthesiology 95:708, 2001.
123. Hale JR, de Boer JZ, Chanton JP, et al: Questioning
the Delphic oracle. Sci Am 289:66, 2003.
124. Tymoczko D: The nitrous oxide philosopher. Atlan-
tic Monthly 277, 1996.
125. Beecher HK: Anesthesia’s second power: Probing
the mind. Science 105:164, 1947.
126. Tononi G: An information integration theory of
consciousness. BMC Neurosci 5:42, 2004.
127. Tononi G, Sporns O: Measuring information inte-
gration. BMC Neurosci 4:31, 2003.
128. von der Malsburg C: The binding problem of
neural networks.
In
Llinas R, Churchland PS (eds):
The Mind-Brain Continuum. Cambridge, MA, MIT
Press, 1996.
129. von der Malsburg C: The correlation theory of brain
function.
In
MPI., Biophysical Chemistry, Internal
Report. , Max Planck Institute for Biophysical Che-
mistry, Göttingen 1981, p 81.
130. Singer W: Neuronal synchronization: A solution to
the binding problem?
In
Churchland PS (ed): The
Mind-Brain Continuum. Cambridge, MA, MIT
Press, 1996, p 101.
131. Singer W: Putative functions of temporal correla-
tions in neocortical processing.
In
Koch C, Davis J
(eds): Large Scale Neuronal Theories of the Brain.
Cambridge, MA, MIT Press, 1994, p 201.
132. Kanwisher N, McDermott J, Chun MM: The fusi-
form face area: A module in human extrastriate
cortex specialized for face perception. J Neurosci
17:4302, 1997.
133. Maunsell JH, Van Essen DC: Functional properties
of neurons in middle temporal visual area of the
macaque monkey. I. Selectivity for stimulus direc-
tion, speed, and orientation. J Neurophysiol 49:1127,
1983.
134. Tanaka K: Neuronal mechanisms of object recogni-
tion. Science 262:685, 1993.
135. Hebb DO: The Organization of Behavior: A Neu-
ropsychological Theory. New York, Wiley, 1949.
136. Gray CM: The temporal correlation hypothesis of
visual feature in
tegration:Stillalive and well.Neuron
24:31, 1999.
137. Joliot M,Ribary U,Llinas R: Human oscillatory brain
activity near 40 Hz coexists with cognitive temporal
binding. Proc Natl Acad Sci USA 91:11748, 1994.
138. Rodriguez E,George N,Lachaux JP,et al:Perception’s
shadow: Long-distance synchronization of human
brain activity. Nature 397:430, 1999.
Sueño, memoria y consciencia
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Sección I
Fisiología y anestesia
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