471. Bhana N, Goa KL, McClellan KJ: Dexmedetomi-
dine. Drugs 59:263–268, 2000.
472. Virtanen R, Savola JM, Saano V, Nyman L: Charac-
terization of the selectivity, specificity and potency
of medetomidine as an alpha 2-adrenoceptor
agonist. Eur J Pharmacol 150:9–14, 1988.
473. Dyck JB, Maze M, Haack C, et al: Computer-con-
trolled infusion of intravenous dexmedetomidine
hydrochloride in adult human volunteers. Anesthe-
siology 78:821–828, 1993.
474. Dyck JB, Maze M, Haack C, et al: The pharmacoki-
netics and hemodynamic effects of intravenous and
intramuscular dexmedetomidine hydrochloride in
adult human volunteers. Anesthesiology 78:813–
820, 1993.
475. De Wolf AM, Fragen RJ, Avram MJ, et al: The phar-
macokinetics of dexmedetomidine in volunteers
with severe renal impairment. Anesth Analg
93:1205–1209, 2001.
476. Venn RM, Karol MD, Grounds RM: Pharmacoki-
netics of dexmedetomidine infusions for sedation
of postoperative patients requiring intensive caret.
Br J Anaesth 88:669–675, 2002.
477. Aantaa R, Jalonen J: Perioperative use of alpha
2
-
adrenoceptor agonists and the cardiac patient. Eur
J Anaesthesiol 23:361–372, 2006.
478. Paris A,Tonner PH: Dexmedetomidine in anaesthe-
sia. Curr Opin Anaesthesiol 18:412–418, 2005.
479. Guo TZ, Jiang JY, Buttermann AE, Maze M: Dex-
medetomidine injection into the locus ceruleus
produces antinociception. Anesthesiology 84:873–
881, 1996.
480. Venn RM, Bradshaw CJ, Spencer R, et al: Prelimi-
nary UK experience of dexmedetomidine, a novel
agent for postoperative sedation in the intensive
care unit. Anaesthesia 54:1136–1142, 1999.
481. Venn RM, Hell J, Grounds RM: Respiratory effects
of dexmedetomidine in the surgical patient requi-
ring intensive care. Crit Care 4:302–308, 2000.
482. Kress JP, Pohlman AS, O’Connor MF, Hall JB: Daily
interruption of sedative infusions in critically ill
patients undergoing mechanical ventilation. N Engl
J Med 342:1471–1477, 2000.
483. Nelson LE, Lu J, Guo T, et al: The alpha
2
-adrenocep-
tor agonist dexmedetomidine converges on an
endogenous sleep-promoting pathway to exert its
sedative effects. Anesthesiology 98:428–436, 2003.
484. Nacif-Coelho C, Correa-Sales C, Chang LL, Maze
M: Perturbation of ion channel conductance alters
the hypnotic response to the alpha 2-adrenergic
agonist dexmedetomidine in the locus coeruleus of
the rat. Anesthesiology 81:1527–1534, 1994.
485. Angst MS, Ramaswamy B, Davies MF, Maze M:
Comparative analgesic and mental effects of increa-
sing plasma concentrations of dexmedetomidine
and alfentanil in humans. Anesthesiology 101:744–
752, 2004.
486. Ramsay MA, Luterman DL: Dexmedetomidine as a
total intravenous anesthetic agent. Anesthesiology
101:787–790, 2004.
487. Aho M, Erkola O, Kallio A, et al: Comparison of
dexmedetomidine and midazolam sedation and
antagonism of dexmedetomidine with atipamezole.
J Clin Anesth 5:194–203, 1993.
488. Reid K, Hayashi Y, Guo TZ, et al: Chronic adminis-
tration of an alpha 2 adrenergic agonist desensitizes
rats to the anesthetic effects of dexmedetomidine.
Pharmacol Biochem Behav 47:171–175, 1994.
489. Maccioli GA: Dexmedetomidine to facilitate drug
withdrawal. Anesthesiology 98:575–577, 2003.
490. Davies MF, Haimor F, Lighthall G, Clark JD: Dex-
medetomidine fails to cause hyperalgesia after ces-
sation of chronic administration. Anesth Analg
96:195–200, 2003.
491. Hayashi Y, Guo TZ, Maze M: Hypnotic and analge-
sic effects of the alpha 2-adrenergic agonist dexme-
detomidine in morphine-tolerant rats. Anesth
Analg 83:606–610, 1996.
492. Asano T, Dohi S, Ohta S, et al: Antinociception by
epidural and systemic alpha(2)-adrenoceptor ago-
nists and their binding affinity in rat spinal cord and
brain. Anesth Analg 90:400–407, 2000.
493. Tryba M, Gehling M: Clonidine—a potent analge-
sic adjuvant. Curr Opin Anaesthesiol 15:511–517,
2002.
494. Eisenach JC, De Kock M, Klimscha W: Alpha(2)-
adrenergic agonists for regional anesthesia: A clini-
cal review of clonidine (1984-1995).Anesthesiology
85:655–674, 1996.
495. Eisenach JC, Shafer SL, Bucklin BA, et al: Pharma-
cokinetics and pharmacodynamics of intraspinal
dexmedetomidine in sheep. Anesthesiology
80:1349–1359, 1994.
496. Aho MS, Erkola OA, Scheinin H, et al: Effect of
intravenously administered dexmedetomidine on
pain after laparoscopic tubal ligation. Anesth Analg
73:112–118, 1991.
497. Hall JE, Uhrich TD, Barney JA, et al: Sedative,
amnestic, and analgesic properties of small-dose
dexmedetomidine infusions. Anesth Analg 90:699–
705, 2000.
498. Cortinez LI, Hsu YW, Sum-Ping ST, et al: Dexme-
detomidine pharmacodynamics, part II: Crossover
comparison of the analgesic effect of dexmedetomi-
dine and remifentanil in healthy volunteers. Anes-
thesiology 101:1077–1083, 2004.
499. Maier C, Steinberg GK, Sun GH, et al: Neuropro-
tection by the alpha 2-adrenoreceptor agonist dex-
medetomidine in a focal model of cerebral ischemia.
Anesthesiology 79:306–312, 1993.
500. Hoffman WE, Kochs E, Werner C, et al: Dexmede-
tomidine improves neurologic outcome from
incomplete ischemia in the rat: Reversal by the
alpha 2-adrenergic antagonist atipamezole. Anes-
thesiology 75:328–332, 1991.
501. Kuhmonen J, Pokorny J, Miettinen R, et al: Neuro-
protective effects of dexmedetomidine in the gerbil
hippocampus after transient global ischemia. Anes-
thesiology 87:371–377, 1997.
502. Engelhard K,Werner C, Kaspar S, et al: Effect of the
alpha2-agonist dexmedetomidine on cerebral neu-
rotransmitter concentrations during cerebral ische-
mia in rats. Anesthesiology 96:450–457, 2002.
503. Talke P, Bickler PE: Effects of dexmedetomidine on
hypoxia-evoked glutamate release and glutamate
receptor activity in hippocampal slices.Anesthesio-
logy 85:551–557, 1996.
504. Talke P, Tong C, Lee HW, et al: Effect of dexmede-
tomidine on lumbar cerebrospinal fluid pressure in
humans. Anesth Analg 85:358–364, 1997.
505. Karlsson BR, Forsman M, Roald OK, et al: Effect of
dexmedetomidine, a selective and potent alpha
2-agonist, on cerebral blood flow and oxygen con-
sumption during halothane anesthesia in dogs.
Anesth Analg 71:125–129, 1990.
506. Zornow MH, Fleischer JE, Scheller MS, et al: Dex-
medetomidine, an alpha 2-adrenergic agonist,
decreases cerebral blood flow in the isoflurane-
anesthetized dog. Anesth Analg 70:624–630, 1990.
507. Zornow MH, Maze M, Dyck JB, Shafer SL: Dexme-
detomidine decreases cerebral blood flow velocity
in humans. J Cereb Blood Flow Metab 13:350–353,
1993.
508. Bekker A, Sturaitis MK: Dexmedetomidine for neu-
rological surgery. Neurosurgery 57:1–10, 2005.
509. Drummond JC, Dao AV, Roth DM, et al: Effect of
dexmedetomidine on cerebral blood flow velocity,
cerebral metabolic rate, and carbon dioxide res-
ponse in normal humans. Anesthesiology 108:225–
232, 2008.
510. Mirski MA, Rossell LA, McPherson RW, Traystman
RJ: Dexmedetomidine decreases seizure threshold
in a rat model of experimental generalized epilepsy.
Anesthesiology 81:1422–1428, 1994.
511. Halonen T, Kotti T, Tuunanen J, et al: Alpha 2-adre-
noceptor agonist, dexmedetomidine, protects
against kainic acid-induced convulsions and neuro-
nal damage. Brain Res 693:217–224, 1995.
512. Weinger MB, Segal IS, Maze M: Dexmedetomidine,
acting through central alpha-2 adrenoceptors, pre-
vents opiate-induced muscle rigidity in the rat.
Anesthesiology 71:242–249, 1989.
513. Schmucker P, van Ackern K, Franke N, et al: [Effect
of the intravenous administration of lormetazepam
on hemodynamics and arterial blood gases in
patients with coronary heart disease]. Anaesthetist
31:557–563, 1982.
514. Karhuvaara S, Kallio A, Koulu M, et al: No involve-
ment of alpha 2-adrenoceptors in the regulation of
basal prolactin secretion in healthy men. Psycho-
neuroendocrinology 15:125–129, 1990.
515. Ebert TJ, Hall JE, Barney JA, et al: The effects of
increasing plasma concentrations of dexmedetomi-
dine in humans. Anesthesiology 93:382–394, 2000.
516. Yung-Wei H, Robertson K,Young C, et al: Compare
the respiratory effects of remifentanil and dexme-
detomidine. Anesthesiology 95:A1357, 2001.
517. Arain SR, Ebert TJ: The efficacy, side effects, and
recovery characteristics of dexmedetomidine versus
propofol when used for intraoperative sedation.
Anesth Analg 95:461–466, 2002.
518. Hsu YW, Cortinez LI, Robertson KM, et al: Dexme-
detomidine pharmacodynamics, part I: Crossover
comparison of the respiratory effects of dexmede-
tomidine and remifentanil in healthy volunteers.
Anesthesiology 101:1066–1076, 2004.
519. Lou YP, Franco-Cereceda A, Lundberg JM: Variable
alpha 2-adrenoceptor-mediated inhibition of bron-
choconstriction and peptide release upon activation
of pulmonary afferents. Eur J Pharmacol 210:173–
181, 1992.
520. Hogue CW Jr, Talke P, Stein PK, et al: Autonomic
nervous system responses during sedative infusions
of dexmedetomidine. Anesthesiology 97:592–598,
2002.
521. Riker RR, Fraser GL: Adverse events associated
with sedatives, analgesics, and other drugs that
provide patient comfort in the intensive care unit.
Pharmacotherapy 25:8S–18S, 2005.
522. Roekaerts P, Prinzen F, Willingers H: The effect of
dexmedetomidine on systemic haemodynamics,
regional myocardial function and blood flow during
coronary artery stenosis in acute anaesthetized
dogs. J Cardiothorac Anesth 8:58, 1994.
523. Willigers HM, Prinzen FW, Roekaerts PM, et al:
Dexmedetomidine decreases perioperative myocar-
dial lactate release in dogs. Anesth Analg 96:657–
664, 2003.
524. Nishina K, Mikawa K, Uesugi T, et al: Efficacy of
clonidine for prevention of perioperative myocar-
dial ischemia: A critical appraisal and meta-analysis
of the literature. Anesthesiology 96:323–329, 2002.
525. Wallace AW, Galindez D, Salahieh A, et al: Effect of
clonidine on cardiovascular morbidity and morta-
lity after noncardiac surgery. Anesthesiology
101:284–293, 2004.
526. Venn M, Newman J, Grounds M: A phase II study
to evaluate the efficacy of dexmedetomidine for
sedation in the medical intensive care unit. Inten-
sive Care Med 29:201–207, 2003.
527. Karhuvaara S, Kallio A, Salonen M, et al: Rapid
reversal of alpha 2-adrenoceptor agonist effects by
Anestésicos intravenosos
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Sección II
Farmacología y anestesia
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