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REUNIÓN 2

13

8. Sospecha de sobredosis.

9. Evaluación del cumplimiento de los pacientes que presentan eventos

trombóticos durante el tratamiento.

En conclusión, en ciertas situaciones especiales es necesaria la medi-

ción del anticoagulante mediante pruebas básicas de hemostasia. Para

que resultase de utilidad esta medición estas pruebas deberían ser

sencillas, asequibles económicamente y estar disponibles en todos los

laboratorios.

Bibliografía

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 Pengo V, Crippa L, Falanga A, Finazzi G, Marongiu F, Palareti F, et al.; Italian Federation

of Thrombosis Centers. Questions and answers on the use of dabigatran and perspec-

tives on the use of other new oral anticoagulants in patients with atrial fibrillation. A

consensus document of the Italian Federation of Thrombosis Centers (FCSA). Thromb

Haemost. 2011;106:868-76.

2. Van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, et al. Dabi-

gatran etexilate—a novel, reversible, oral direct thrombin inhibitor: Interpretation

of coagulation assays and reversal of anticoagulant activity. Thromb Haemost.

2010;103:1116-27.

3. Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogné JM. Impact of

dabigatran on a large panel of routine or specific coagulation assays. Labora-

tory recommendations for monitoring of dabigatran etexilate. Thromb Haemost.

2012;107:985-97.

4. Barrett YC, Wang Z, Frost C, Shenker A. Clinical laboratory measurement of direct

factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb

Haemost. 2010;104:1263-71.

5. Tripodi A, Chantarangkul V, Guinet C, Samama MM.The International Normalized Ratio

calibrated for rivaroxaban has the potential to normalize prothrombin time results

for rivaroxaban-treated patients. results of an in vitro study. J Thromb Haemost.

2011;9:226-8.

6. Samama MM, Mendell J, Guinet C, Le Flem L, Kunitada S. In vitro study of the anti-

coagulant effects of edoxaban and its effect on thrombin generation in comparison to

fondaparinux. Thromb Res. 2012;129:e77-82.