149. Kang HK, Jeong YY, Choi JH, et al: Three-dimensio-
nal multi-detector row CT portal venography in the
evaluation of portosystemic collateral vessels in
liver cirrhosis. Radiographics 22:1053, 2002.
150. Kaplowitz N: Mechanisms of liver cell injury.
J Hepatol 32:39, 2000.
151. Nielsen VG, McCammon AT, Tan S, et al: Xanthine
oxidase inactivation attenuates postocclusion shock
after descending thoracic aorta occlusion and
reperfusion in rabbits. J Thorac Cardiovasc Surg
110:715, 1995.
152. Jaeschke H, Gores GJ, Cederbaum AI, et al: Mecha-
nisms of hepatotoxicity. Toxicol Sci 65:166, 2002.
153. Carden DL,Granger DN: Pathophysiology of ischae-
mia-reperfusion injury. J Pathol 190:255, 2000.
154. Arai M, Thurman RG, Lemasters JJ: Ischemic pre-
conditioning of rat livers against cold storage–
reperfusion injury: Role of nonparenchymal cells
and the phenomenon of heterologous preconditio-
ning. Liver Transpl 7:292, 2001.
155. Weinbroum A, Nielsen VG, Tan S, et al: Liver ische-
mia-reperfusion increases pulmonary permeability
in rat: Role of circulating xanthine oxidase. Am J
Physiol 268:G988, 1995.
156. Kaplowitz N, Tsukamoto H: Oxidative stress and
liver disease. Prog Liver Dis 14:131, 1996.
157. Ursini F, Maiorino M, Roveri A: Phospholipid
hydroperoxide glutathione peroxidase (PHGPx):
More than an antioxidant enzyme? Biomed Environ
Sci 10:327, 1997.
158. Doroshow JH, Akman S, Chu FF, et al: Role of the
glutathione–glutathione peroxidase cycle in the
cytotoxicity of the anticancer quinones. Pharmacol
Ther 47:359, 1990.
159. Michiels C, Raes M, Toussaint O, et al: Importance
of Se-glutathione peroxidase, catalase, and Cu/
Zn-SOD for cell survival against oxidative stress.
Free Radic Biol Med 17:235, 1994.
160. Luo GM, Ren XJ, Liu JQ, et al: Towards more effi-
cient glutathione peroxidase mimics: Substrate
recognition and catalytic group assembly. Curr Med
Chem 10:1151, 2003.
161. Kim JS, Qian T, Lemasters JJ: Mitochondrial per-
meability transition in the switch from necrotic to
apoptotic cell death in ischemic rat hepatocytes.
Gastroenterology 124:494, 2003.
162. Sawaya DE Jr, Brown M, Minardi A, et al: The role
of ischemic preconditioning in the recruitment of
rolling and adherent leukocytes in hepatic venules
after ischemia/reperfusion. J Surg Res 85:163,
1999.
163. Kurose I, Argenbright LW, Wolf R, et al: Ischemia/
reperfusion-induced microvascular dysfunction:
Role of oxidants and lipid mediators. Am J Physiol
272:H2976, 1997.
164. Yokoyama Y, Beckman JS, Beckman TK, et al: Cir-
culating xanthine oxidase: Potential mediator of
ischemic injury. Am J Physiol 258:G564, 1990.
165. Nielsen VG, Tan S,Weinbroum A, et al: Lung injury
after hepatoenteric ischemia-reperfusion: Role of
xanthine oxidase. Am J Respir Crit Care Med
154:1364, 1996.
166. Nielsen VG, Tan S, Baird MS, et al: Gastric intramu-
cosal pH and multiple organ injury: Impact of
ischemia-reperfusion and xanthine oxidase. Crit
Care Med 24:1339, 1996.
167. NielsenVG,Tan S,Baird MS,et al: Xanthine oxidase
mediates myocardial injury after hepatoenteric
ischemia-reperfusion. Crit Care Med 25:1044,
1997.
168. Nielsen VG, Tan S, Kirk KA, et al: Halothane and
xanthine oxidase increase hepatocellular enzyme
release and circulating lactate after ischemia-reper-
fusion in rabbits. Anesthesiology 87:908, 1997.
169. NielsenVG,Tan S,BrixAE,et al: Hextend (hetastarch
solution) decreases multiple organ injury and xan-
thine oxidase release after hepatoenteric ischemia-
reperfusion in rabbits. Crit Care Med 25:1565,
1997.
170. Pesonen EJ, Linder N, Raivio KO, et al: Circulating
xanthine oxidase and neutrophil activation during
human liver transplantation. Gastroenterology
114:1009, 1998.
171. Tan S, Yokoyama Y, Dickens E, et al: Xanthine
oxidase activity in the circulation of rats following
hemorrhagic shock. Free Radic Biol Med 15:407,
1993.
172. Radi R, Rubbo H, Bush K, et al: Xanthine oxidase
binding to glycosaminoglycans: Kinetics and supe-
roxide dismutase interactions of immobilized xan-
thine oxidase–heparin complexes. Arch Biochem
Biophys 339:125, 1997.
173. Adachi T, Fukushima T, Usami Y, et al: Binding of
human xanthine oxidase to sulphated glycosamino-
glycans on the endothelial-cell surface. Biochem J
289:523, 1993.
174. Beckman JS, Koppenol WH: Nitric oxide, supe-
roxide, and peroxynitrite: The good, the bad, and
ugly. Am J Physiol 271:C1424, 1996.
175. Toledo-Pereyra LH: Liver preservation: Experimen-
tal and clinical observations. Transplant Proc
20:965, 1988.
176. Jamieson NV, Sundberg R, Lindell S, et al: The 24- to
48-hour preservation of canine liver by simple cold
storage using UW lactobionate solution. Transplant
Proc 21:1292, 1989.
177. Marsh DC,Vreugdenhil PK, Mack VE, et al: Glycine
protects hepatocytes from injury caused by anoxia,
cold ischemia and mitochondrial inhibitors, but not
injury caused by calcium ionophores or oxidative
stress. Hepatology 17:91, 1993.
178. Adkison D, Hollwarth ME, Benoit JN, et al: Role of
free radicals in ischemia-reperfusion injury to the
liver. Acta Physiol Scand 548:101, 1986.
179. Jaeschke H, Lemasters JJ: Apoptosis versus oncotic
necrosis in hepatic ischemia/reperfusion injury.
Gastroenterology 125:1246, 2003.
180. Sindram D, Rudiger HA, Upadhya AG, et al: Ische-
mic preconditioning protects against cold ischemic
injury through an oxidative stress dependent
mechanism. J Hepatol 36:78, 2002.
181. Lehnert M, Arteel GE, Smutney OM, et al: Depen-
dence of liver injury after hemorrhage/resuscitation
in mice on NADPH oxidase–derived superoxide.
Shock 19:345, 2003.
182. Schemmer P, Connor HD, Arteel GE, et al: Reper-
fusion injury in livers due to gentle in situ organ
manipulation during harvest involves hypoxia and
free radicals. J Pharmacol Exp Ther 290:235,
1999.
183. Lee YG, Lee SH, Lee SM: Role of Kupffer cells in
cold/warm ischemia-reperfusion injury of rat liver.
Arch Pharmacol Res 23:620, 2000.
184. Schauer RJ, Bilzer M, Kalmuk S, et al: Microcircu-
latory failure after rat liver transplantation is related
to Kupffer cell–derived oxidant stress but not invol-
ved in early graft dysfunction. Transplantation
72:1692, 2001.
185. Radi R, Cassina A, Hodara R: Nitric oxide and
peroxynitrite interactions with mitochondria. Biol
Chem 383:401, 2002.
186. Warle MC, Farhan A, Metselaar HJ, et al: In vitro
cytokine production of TNF
a
and IL-13 correlates
with acute liver transplant rejection. Hum Immunol
62:1258, 2001.
187. Imamura H, Sutto F, Brault A, et al: Role of Kupffer
cells in cold ischemia/reperfusion injury of rat liver.
Gastroenterology 109:189, 1995.
188. Kerkweg U, Jacob M, De Groot H, et al: Cold-indu-
ced apoptosis of rat liver endothelial cells: Contri-
butionof mitochondrialalterations.Transplantation
76:501, 2003.
189. Doeppner TR, Grune T, de Groot H, et al: Cold-
induced apoptosis of rat liver endothelial cells:
Involvement of the proteasome. Transplantation
75:1946, 2003.
190. Sindram D, Porte RJ, Hoffman MR, et al: Platelets
induce sinusoidal endothelial cell apoptosis upon
reperfusion of the cold ischemic rat liver. Gastroen-
terology 118:183, 2000.
191. Lemasters JJ,Thurman RG: Reperfusion injury after
liver preservation for transplantation. Annu Rev
Pharmacol Toxicol 37:327, 1997.
192. Shedlofsky SI, Israel BC, McClain CJ, et al: Endo-
toxin administration to humans inhibits hepatic
cytochrome P450–mediated drug metabolism.
J Clin Invest 94:2209, 1994.
193. Gerson RJ, Casini A, Gilfor D, et al: Oxygen-media-
ted cell injury in the killing of cultured hepatocytes
by acetaminophen. Biochem Biophys Res Commun
126:1129, 1985.
194. Casini A, Giorli M, Hyland RJ, et al: Mechanisms of
cell injury in the killing of cultured hepatocytes by
bromobenzene. J Biol Chem 257:6721, 1982.
195. Tang W, Stearns RA, Bandiera SM, et al: Studies on
cytochrome P-450–mediated bioactivation of diclo-
fenac in rats and in human hepatocytes: Identifica-
tion of glutathione conjugated metabolites. Drug
Metab Dispos 27:365, 1999.
196. Wang M, Dickinson RG: Disposition and covalent
binding of diflunisal and diflunisal acyl glucuronide
in the isolated perfused rat liver.Drug Metab Dispos
26:98, 1998.
197. Tang W, Borel AG, Abbott FS: Conjugation of glu-
tathione with a toxic metabolite of valproic acid,
(E)-2-propyl-2,4-pentadienoic acid,catalyzed by rat
hepatic glutathione-
S
-transferases. Drug Metab
Dispos 24:436, 1996.
198. Patel T: Apoptosis in hepatic pathophysiology. Clin
Liver Dis 4:295, 2000.
199. Fau D, Lekehal M, Farrell G, et al: Diterpenoids
from germander, an herbal medicine, induce apop-
tosis in isolated rat hepatocytes. Gastroenterology
113:1334, 1997.
200. Haouzi D, Lekehal M, Moreau A, et al: Cytochrome
P450–generated reactive metabolites cause mito-
chondrial permeability transition, caspase activa-
tion, and apoptosis in rat hepatocytes. Hepatology
32:303, 2000.
201. Lewis W, Dalakas MC: Mitochondrial toxicity of
antiviral drugs. Nat Med 1:417, 1995.
202. Gut J, Christen U, Huwyler J, et al: Molecular
mimicry of trifluoroacetylated human liver protein
adducts by constitutive proteins and immunoche-
mical evidence for its impairment in halothane
hepatitis. Eur J Biochem 210:569, 1992.
203. Kretz-Rommel A, Boelsterli UA: Cytotoxic acti-
vity of T cells and non-T cells from diclofenac-
immunized mice against cultured syngeneic
hepatocytes exposed to diclofenac. Hepatology
22:213, 1995.
204. Bourdi M, Larrey D, Nataf J, et al: Anti-liver endo-
plasmic reticulum autoantibodies are directed
against human cytochrome P-450IA2. A specific
marker of dihydralazine-induced hepatitis. J Clin
Invest 85:1967, 1990.
205. Lecoeur S,Bonierbale E,Challine D,et al: Specificity
of in vitro covalent binding of tienilic acid metabo-
lites to human liver microsomes in relationship to
the type of hepatotoxicity: Comparison with two
directly hepatotoxic drugs. Chem Res Toxicol 7:434,
1994.
204
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