Miller Anestesia

surgery: Relationship to neuropsychologic deficit.

J Thorac Cardiovasc Surg 130:1022-1027, 2005.

33. Bergh C, Backstrom, Jonsson H, et al: In the eye of

both patient and spouse: Memory is poor 1 to 2

years after coronary bypass and angioplasty. Ann

Thorac Surg 4:689-694, 2002.

34. Gallo LC, Malek MJ, Gilbertson AD, Moore JL:

Perceived cognitive function and emotional distress

following coronary artery bypass surgery. J Behav

Med 28:433-442, 2005.

35. Johnson T, Monk T, Rasmussen LS, et al for the

ISPOCD2 investigators. Postoperative cognitive

dysfunction in middle-aged patients. Anesthesio-

logy 96:1351-1357, 2002.

36. Newman S, Klinger L, Venn G, et al: Subjective

reports of cognition in relation to assessed cognitive

performance following coronary artery bypass

surgery. J Psychosom Res 33:227-233, 1989.

37. Vingerhoets G, De Soete G, Jannes C: Subjective

complaints versus neuropsychological test perfor-

mance after cardiopulmonary bypass. J Psychosom

Res 39:843-853, 1995.

38. Newman MF, Mathew JP, Grocott HP, et al: Central

nervous system injury associated with cardiac

surgery. Lancet 368:694-703, 2006.

39. Murkin JM, Newman SP, Stump DA, Blumenthal JA:

Statement of consensus on assessment of neurobe-

havioral outcomes after cardiac surgery. AnnThorac

Surg 59:1289-1295, 1995.

40. Smith P, Treasure T, Newman S, et al: Cerebral con-

sequences of cardiopulmonary bypass. Lancet

1:823-825, 1986.

41. Venn G, Sherry K, Treasure T, et al: Cerebral blood

flow during cardiopulmonary bypass. Eur J Cardio-

thorac Surg 2:360-363, 1988.

42. Brown WR, Moody DM, Challa VR, et al: Longer

duration or cardiopulmonary bypass is associated

with greater numbers of microemboli. Stroke

31:707-713, 2000.

43. Stump DA, Rogers AT, Hammon JW, Newman SP:

Cerebral emboli and cognitive outcome after

cardiac surgery. J Cardiothorac Vasc Anesth 10:113-

119, 1996.

44. Clark RE, Brillman J, Davis DA, et al: Microemboli

during coronary artery bypass grafting: Genesis and

effect on outcome. J Thorac Cardiovasc Surg

109:249-258, 1995.

45. Sylivris S, Levi C, Matalanis G, et al: Pattern and

significance of cerebral microemboli during coro-

nary artery bypass grafting. Ann Thorac Surg

66:1674-1678, 1998.

46. Arrowsmith JE, Harrison MJG, Newman SP, et al:

Neuroprotection of the brain during cardiopulmo-

nary bypass: A randomized trial of remacemide

during coronary artery bypass in 171 patients.

Stroke 29:2357-2362, 1998.

47. Stroobant N, van Nooten G, van Bellegham Y,

Vingerhouts G: Relationship between neurocog-

nitive impairment, embolic load, and cerebrovas-

cular reactivity following on- and off-pump

coronary artery bypass grafting. Chest 127:1967-

1976, 2005.

48. Patel RL, Turtle MR, Chambers DJ, et al: Alpha-stat

acid-base regulation during cardiopulmonary

bypass improves neuropsychologic outcome in

patients undergoing coronary artery bypass graf-

ting. J Thorac Cardiovasc Surg 111:1267-1279,

1996.

49. Stephan H, Weyland A, et al: Acid-base manage-

ment during hypothermic cardiopulmonary bypass

does not affect cerebral metabolism but does affect

blood flow and neurological outcome. Br J Anaesth

69:51-57, 1992.

50. Bashein G, Townes BD, Nessley MA: A randomised

trial of carbon dioxide management during hypo-

thermic cardiopulmonary bypass. Anaesthesiology

72:7-15, 1990.

51. Murkin JM, Martzke JS, Buchan AM, et al: A ran-

domised study of the influence of perfusion techni-

que and pH management strategy in 316 patients

undergoing coronary artery bypass surgery. II. Neu-

rologic and cognitive outcomes. J Thorac Cardio-

vasc Surg 110:346-362, 1995.

52. Martin TD, Craver JM, Gott JP, et al: Prospective,

randomised trial of retrograde warm blood cardio-

plegia: Myocardial benefit and neurologic threat.

Ann Thorac Surg 57:298-302, 1994.

53. Mora CT, Henson MB, Weintraub WS, et al: The

effect of temperature management during cardio-

pulmonary bypass on neurologic outcomes in

patients undergoing coronary artery revasculari-

sation. J Thorac Cardiovasc Surg 112:514-522,

1996.

54. Regragui I, Birdi I, Izzat MB, et al: The effects of

cardiopulmonary bypass temperature on neuropsy-

chologicaloutcomeaftercoronaryarteryoperations:

A prospective randomised trial. J Thorac Cardio-

vasc Surg 112:1036-1045, 1996.

55. Heyer E, Adams D, Delphin E, et al: Cerebral dys-

function after coronary artery bypass grafting done

with mild or moderate hypothermia. J Thorac Car-

diovasc Surg 114:270-277, 1997.

56. McLean RF, Wong BI, Naylor CD, et al: Cardiopul-

monary bypass, temperature, and cerebral nervous

system dysfunction. Circulation 90:250-255, 1994.

57. Ploude G, Leduc A, Morin J, et al: Temperature

during cardiopulmonary bypass for coronary artery

operations does not influence postoperative cogni-

tive function: A prospective randomized trial.

J Thorac Cardiovasc Surg 114:123-128, 1997.

58. Buss MI, McLean RF, Wong BI, et al: Cardiopulmo-

nary bypass, rewarming and central nervous

system dysfunction. Ann Thorac Surg 61:1423-

1427, 1996.

59. Nathan HJ, Wells GA, Munson JL, Wozny D: Neu-

roprotective effect of mild hypothermia in patients

undergoing coronary artery with cardiopulmonary

bypass: A randomized trial. Circulation 104(Suppl

I)I-85-I-91, 2001.

60. Nathan HJ, Rodriguez R, Wozny D, et al: Neuropro-

tective effect of mild hypothermia in patients

undergoing coronary artery surgery with cardio-

pulmonary bypass: Five-year follow-up of a rando-

mizedtrial.JThoracCardiovascSurg133:1206-1211,

2007.

61. and the Neurologic Outcomes Research Group

(NORG) and the Cardiothoracic Anesthesiology

Research Endeavors (CARE) Investigators, Grocott

HP, Mackensen GB, Grigore AM, et al: Postopera-

tive hyperthermia is associated with cognitive dys-

function after coronary artery bypass surgery.

Stroke 33:537-541, 2002.

62. Padayachee TS, Parsons S, Theobald R, et al: The

effect of arterial filtration on reduction of gaseous

microemboli in the middle cerebral artery during

cardiopulmonary bypass. Ann Thorac Surg 45:647-

649, 1988.

63. Pugsley W, Klinger L, Paschalis C, et al: The impact

of microemboli during cardiopulmonary bypass on

neuropsychological functioning. Stroke 25:1393-

1399, 1994.

64. Aris A, Solanes H, Camera ML, et al: Arterial line

filtration during cardiopulmonary bypass: Neurolo-

gic, neuropsychologic, and haematologic studies.

J Thorac Cardiovasc Surg 91:526-533, 1986.

65. Garvey JW, Willner A, Wolpwitz A, et al: The effect

of arterial filtration during open heart surgery on

cerebral function. Circulation 68(Suppl II)II-125-

II-128, 1983.

66. Habib RH, Zacharias A, Schwann TA, et al: Adverse

effects of low hematocrit during cardiopulmonary

bypass in the adult: Should current practice be

changed? J Thorac Cardiovascular Surg 125:1438-

1450, 2003.

67. Karkouti K, Djaini G, Borger M, et al: Low hemato-

crit during cardiopulmonary bypass is associated

with increased risk of preoperative stroke in cardiac

surgery. Ann Thorac Surg 80:1381-1387, 2005.

68. Harrison MJG, Stygall J, Whitaker DC, et al: Hema-

tocrit during cardiopulmonary bypass. Ann Thorac

Surg 82:1166, 2006.

69. Grocott HP, Yoshitani K: Neuroprotection during

cardiac surgery. J Anesth 21:367-377, 2007.

70. Puskas F, Grocott HP, White WD, et al: Intraopera-

tive hyperglycemia and cognitive decline after

CABG. Ann Thorac Surg 84:1467-1473, 2007.

71. Padayachee TS, Parsons S, Theobald R, et al: The

detection of microemboli in the middle cerebral

artery during cardiopulmonary bypass: A transcra-

nial Doppler ultrasound investigation using mem-

brane and bubble oxygenators. Ann Thorac Surg

44:298-302, 1987.

72. Carlson R, Lande A, Landis B, et al: The Lande-

Edwards membrane oxygenator during heart

surgery: Oxygen transfer, microemboli counts, and

Bender-Gestalt Visual Motor Tests scores. J Thorac

Cardiovasc Surg 66:894-905, 1973.

73. Smith P, Blauth C, Newman S, et al: Cerebral

microembolism and neuropsychological outcome

following coronary artery bypass surgery (CABS)

with either membrane or bubble oxygenator. In

Willner A, Rodewald G (eds): Impact of cardiac

surgery on quality of life. New York, Plenum, 1990,

pp 337-342.

74. van der Heijden GJMG, Nathoe HM, Jansen EWL,

Grobbee DE: Meta-analysis on the effect of off-

pump coronary bypass surgery. Eur J Cardiothorac

Surg 26:81-84, 2004.

75. Parolari A, Alamanni F, Cannata A, et al: Off-pump

versus on-pump coronary artery bypass: Meta-

analysis of currently available randomized trials.

Ann Thorac Surg 76:37-40, 2003.

76. Cheng DC, Bainbridge D, Martin JE, Novick RJ:

Does off-pump coronary artery bypass reduce mor-

tality, morbidity, and resource utilization when

compared with conventional coronary artery

bypass? Ameta-analysis of randomised trials. Anes-

thesiology 102:188-203, 2005.

77. Zamvar V, Williams D, Hall J, et al: Assessment of

neurocognitive impairment after off-pump and

on-pump techniques for coronary artery bypass

graft surgery: Prospective randomised controlled

trial. BMJ 325:1268-1271, 2002.

78. van Dijk D, Jansen EWL, Hijman R, et al: Cognitive

outcome after off-pump and on-pump coronary

artery bypass surgery: A randomized trial. JAMA

287:1405-1412, 2002.

79. van Dijk D, Spoor M, Hijman R, et al: Cognitive and

cardiac outcomes 5 years after off-pump vs on-pump

coronary artery bypass graft surgery. JAMA

297:701-708, 2007.

80. Keizer A, Hijman R, van Dijk D, et al: Cognitive

self-assessment one year after on-pump and off-

pump coronary artery bypass grafting. Ann Thorac

Surg 75:835-839, 2003.

81. Royse AG, Royse CF, Ajani AE, et al: Reduced neu-

ropsychological dysfunction using epiaortic echo-

cardiography and the exclusive Y graft. Ann Thorac

Surg 69:1431-1438, 2000.

82. Simpson BR, Williams M, Scott JF, Smith AC: The

effects of anaesthesia and elective surgery on old

people. Lancet 2:887-893, 1961.

83. Blundell E: A psychological study of the effects of

surgery on eighty-six elderly patients. Br J Soc Clin

Psychol 6:297-303, 1967.

84. Rodriguez RA, Tellier A, Grabowski J, et al: Cogni-

tive dysfunction after total knee arthroplasty.

J Arthroplasty 20:763-771, 2005.

85. Leung JM, Sands LP, Vaurio, Wang Y: Nitrous

oxide does not change the incidence of postope-

rative delirium or cognitive decline in elderly

surgical patients. Br J Anaesth 96:754-760,

2006.

86. Monk TG, Weldon BC, Garvan CW, et al: Predictors

of cognitive dysfunction after major noncardiac

surgery. Anesthesiology 108:18-30, 2008.

87. Heath PJ, Ogg TW, Gilks WR: Recovery after day-

case anesthesia: A 24-hour comparison of recovery

after thiopentone or propofol anaesthesia. Anaes-

thesia 45:911-915, 1990.

88. Cohen RL, MacKenzie AI: Anaesthesia and cogni-

tive functioning: Mental function in postoperative

day patients at time of their release. Anaesthesia

37:47-52, 1982.

89. Canet J, Raeder J, Rasmussen LS, et al: Cognitive

dysfunction after minor surgery in the elderly. Acta

Anaesthesiol Scand 47:1204-1210, 2003.

90. Rohan D, Buggy DJ, Crowley S, et al: Increased inci-

dence of postoperative cognitive dysfunction 24 hr

Disfunción cognitiva y otras complicaciones a largo plazo de la cirugía y la anestesia

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Sección VI

Cuidados postoperatorios