Miller Anestesia

after minor surgery in the elderly. Can J Anaesth

52:137-142, 2005.

91. Hall GM, Peerbhoy D, Shenkin A, et al: Relationship

of the functional recovery after hip arthroplasty to

the neuroendocrine and inflammatory responses.

Br J Anaesth 87:537-542, 2001.

92. Irvine CD, Gardner FV, Davies AH, Lamont PM:

Cognitive testing in patients undergoing carotid

endarterectomy. Eur J Vasc Endovasc Surg 15:195-

204, 1998.

93. Lunn S, Crawley F, Harrison MJ, et al: Impact of

carotid endarterectomy upon cognitive functio-

ning: A systematic review of the literature. Cerebro-

vasc Dis 9:74-81, 1999.

94. Hole A, Terjesen T, Breivik H: Epidural versus

general anaesthesia for total hip arthroplasty in

elderly patients. Acta Anaesth Scand 24:279-287,

1980.

95. Chung FF, Meier RH, Lautenschlager E, et al:

General or spinal anesthesia: Which is better in the

elderly? Anesthesiology 67:422-427, 1987.

96. Asbjorn J, Jakobsen BW, Pilegaard HK, et al: Mental

function in elderly men after surgery during epidu-

ral analgesia. Acta Anaesthesiol Scand 33:369-373,

1989.

97. Rasmussen LS, Johnson T, Kuipers HM, et al, for the

ISPOCD2 Investigators: Does anaesthesia cause

postoperative cognitive dysfunction? A randomised

study of regional versus general anaesthesia in 438

elderly patients. Acta Anaesthesiol Scand 47:260-

266, 2003.

98. Jorgensen LN, Rasmussen LS, Nielson PT, et al:

Antithrombotic efficacy of continuous extradural

analgesia after knee replacement. Br J Anaesth 66:8-

12, 1991.

99. Modig J, Borg T, Karlstrom G, et al: Thromboembo-

lism after total hip replacement: Role of epidural

and general anesthesia. Anesth Analg 62:174-180,

1983.

100. Rodgers A, Walker N, Schug S, et al: Reduction of

postoperative mortality and morbidity with epidu-

ral or spinal anaesthesia: Results from overview of

randomised trials. BMJ 21:1-12, 2000.

101. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al:

Early exposure to common anesthetic agents causes

widespread neurodegeneration in the developing

rat brain and persistent learning deficits. J Neurosci

23:876-882, 2003.

102. Young C, Jevtovic-Todorovic V, Qin YQ, et al: Poten-

tial of ketamine and midazolam, individually or in

combination, to reduce apoptotic neurodegenera-

tion in the infant mouse brain. Br J Pharmacol

146:189-197, 2005.

103. Fredriksson A, Pontén E, Gordh T, Eriksson P: Neo-

natal exposure to a combination of

-methyl-d-

aspartate and gamma-aminobutyric acid type A

receptor anesthetic agents potentiates apoptotic

neurodegeneration and persistent behavioral defi-

cits. Anesthesiology 107:427-436, 2007.

104. Jevtovic-Todorovic V, Beals J, Benshoff N, Olney JW:

Prolonged exposure to inhalational anesthetic

nitrous oxide kills neurons in adult rat brain. Neu-

roscience 122:609-616, 2003.

105. Xie Z, Dong Y, Maeda U, et al: Isoflurane-induced

apoptosis: A potential pathogenic link between deli-

rium and dementia. J Gerontol A Biol Sci Med Sci

61A:1300-1306, 2006.

106. Hanning CD, Blokland A, Johnson M, Perry EK:

Effects of repeated anaesthesia on central choliner-

gic function in the rat cerebral cortex. Eur J Anaes-

thesiol 20:93-97, 2003.

107. Marota JJ, Crosby G, Uhl GR: Selective effects of

pentobarbital and halothane on c-fos and jun-B

gene expression in rat brain. Anesthesiology 77:365-

371, 1992.

108. Hamaya Y, Takeda T, Dohi S, et al: The effects of

pentobarbital, isoflurane, and propofol on imme-

diate-early gene expression in the vital organs of the

rat. Anesth Analg 90:1177-1183, 2000.

109. Culley DJ, Yukhananov RY, Xie Z, et al: Altered

hippocampal gene expression 2 days after general

anesthesia in rats. Eur J Pharmacol 549:71-78,

2006.

110. Dijkstra JB, Van Boxtel MP, Houx PJ, Jolles J: An

operation under general anaesthesia as a risk factor

for age-related cognitive decline: results from a

large cross-sectional population study. J Am Geriatr

Soc 46:1258-1265, 1998.

111. Fong HK, Sands LP, Leung JM: The role of postope-

rative analgesia in delirium and cognitive decline in

elderly patients: A systematic review. Anesth Analg

102:1255-1266, 2006.

112. Newcomer JW, Craft S, Hershey T, et al: Glucocor-

ticoid-induced impairment in declarative memory

performance in adult humans. J Neurosci 14:2047-

2053, 1994.

113. McEwen B, Sapolsky RM: Stress and cognitive

function. Curr Opin Neurobiol 5:205-216, 1995.

114. O’Brien JT: The ‘glucocorticoid cascade’ hypothesis

in man. Br J Psychiatry 170:199-201, 1997.

115. ISPOCD2 Investigators, Rasmussen LS, O’Brien JT,

Silverstein JH, et al: Is peri-operative cortisol secre-

tion related to post-operative cognitive dys-

function? Acta Anaesthesiol Scand 49:1225-1231,

2005.

116. Kohl BA, Deutschman CS: The inflammatory res-

ponse to surgery and trauma. Curr Opin Crit Care

12:325-332, 2006.

117. Lucas SM, Rothwell NJ, Gibson RM: The role of

inflammation in CNS injury and disease. Br J Phar-

macol 147(Suppl 1)S232-S240, 2006.

118. Ramlawi B, Rudolph JL, Mieno S, et al: C-Reactive

protein and inflammatory response associated to

neurocognitive decline following cardiac surgery.

Surgery 140:221-226, 2006.

119. Caplan RA, Posner KL, Ward RJ, Cheney FW:

Adverse respiratory events in anesthesia: A closed

claims analysis. Anesthesiology 72:828-833,

1990.

120. Rosenberg J, Wildschiodtz G, Pedersen MH, et al:

Late postoperative nocturnal episodic hypoxaemia

and associated sleep pattern. Br J Anaesth 72:145-

150, 1994.

121. Moller JT, Svennild I, Johannessen NW, et al: Perio-

perative monitoring with pulse oximetry and late

postoperative cognitive dysfunction. Br J Anaesth

71:340-347, 1993.

122. Strandgaard S: Autoregulation of cerebral blood

flow in hypertensive patients: The modifying

influence of prolonged antihypertensive treatment

on the tolerance to acute, drug induced hypoten-

sion. Circulation 53:720-727, 1976.

123. Stockard JJ, Bickford RG, Schauble JF: Pressure-

dependent cerebral ischemia during cardiopulmo-

nary bypass. Neurology 23:521-529, 1973.

124. Kam PC, Calcroft RM: Peri-operative stroke in

general surgical patients. Anaesthesia 52:879-883,

1997.

125. Selim M: Perioperative stroke. N Engl J Med

356:706-713, 2007.

126. Mahley RW, Rall SC Jr: Apolipoprotein E far more

than a lipid transport protein. Annu Rev Genomics

Hum Genet 1:507-537, 2000.

127. Gerdes LU, Klausen IC, Sihm I, Faergeman O: Apo-

lipoprotein E polymorphism in a Danish popula-

tion compared to findings in 45 other study

populations around the world. Gent Epidemiol

9:15-67, 1992.

128. Corder EH, Saunders AM, Strittmatter WJ, et al:

Gene dose of apolipoprotein E type 4 allele and the

risk of Alzheimer’s disease in late onset families.

Science 261:921-923, 1993.

129. Teasdale GM, Nicoll JA, Murray G, Fiddes M: Asso-

ciation of apolipoprotein E polymorphism with

outcome after head injury. Lancet 350:1069-1071,

1997.

130. Laskowitz DT, Horsburgh, Roses AD: Apolipopro-

tein E and the CNS response to injury. J Cereb

Blood Flow Metab 18:465-471, 1998.

131. Tardiff BE, Newman MF, Saunders AM, et al: Preli-

minary report of a genetic basis for cognitive

decline after cardiac operations. Ann Thorac Surg

64:715-720, 1997.

132. Steed L, Kong R, Stygall J, et al: The role of apolipo-

protein E in cognitive decline after cardiac opera-

tion. Ann Thorac Surg 71:823-826, 2001.

133. Abildstrom H, Christiansen M, Siersma VD, Ras-

mussen LS: ISPOCD2 investigators: Apolipoprotein

E genotype and cognitive dysfunction after noncar-

diac surgery. Anesthesiology 101:855-861, 2004.

134. Heyer EJ, Wilson DA, Sahlein DH, et al: APOE-

epsilon4 predisposes to cognitive dysfunction

following uncomplicated carotid endarterectomy.

Neurology 65:1759-1763, 2005.

135. Galley HF, Mahdy A, Lowes DA: Pharmacogenetics

and anasthesiologists. Pharmacogenomics 6:849-

856, 2005.

136. Nussmeier NA, Arlund C, Slogoff S: Neuropsychia-

tric complications after cardiopulmonary bypass:

Cerebral protection by a barbiturate. Anesthesio-

logy 64:165-170, 1986.

137. Roach GW, Newman MF, Murkin JM, et al: Ineffec-

tiveness of burst suppression in therapy in mitiga-

ting perioperative cerebrovascular dysfunction.

Multicenter Study of Perioperative Ischemia

(McSPI) Research group. Anesthesiology 90:1255-

1264, 1999.

138. Legault C, Furberg CD, Wagenknecht LE, et al:

Nimodipine neuroprotection in cardiac valve repla-

cement: Report of an early terminated trial. Stroke

27:593-598, 1996.

139. Fish KJ, Helms KN, Sarnquist FH, et al: A prospec-

tive, randomized study of the effects of prostacyclin

on neuropsychologic dysfunction after coronary

artery operation. J Thorac Cardiovasc Surg 93:609-

615, 1987.

140. Grieco G, d’Hollosy M, Culliford AT, Jonas S: Eva-

luating neuroprotective agents for clinical anti-

ischemic

benefit

using

neurological

and

neuropsychological changes after cardiac surgery

under cardiopulmonary bypass. Methodological

strategies and results of a double-blind, placebo-

controlled trial of GM1 ganglioside. Stroke 27:858-

874, 1996.

141. Butterworth J, Legault C, Stump DA, et al: A rando-

mized blinded trial of antioxidant pegorgotein: No

reduction in neuropsychological deficits, inotropic

drug support, or myocardial ischemia after coro-

nary artery bypass surgery. J Cardiothorac Vasc

Anesth 13:690-694, 1999.

142. Mitchell SJ, Pellett O, Gorman DF: Cerebral protec-

tion by lidocaine during cardiac operations. Ann

Thorac Surg 67:1117-1124, 1999.

143. Wang D, Wu X, Li J, et al: The effect of lidocaine on

early postoperative cognitive dysfunction after

coronary artery bypass surgery. Anesth Analg

95:1134-1141, 2002.

144. Kong RS, Butterworth J, Aveling W, et al: Clinical

trial of the neuroprotectant clomethiazole in

coronary artery bypass graft surgery: A randomi-

zed controlled trial. Anesthesiology 97:585-591,

2002.

145. Taggart DP, Browne SM, Wade DT, Halligan PW:

Neuroprotection during cardiac surgery: A rando-

mised trial of platelet activating factor antagonist.

Heart 89:897-900, 2003.

146. Mathew JP, Shernan SK, White WD, et al: Prelimi-

nary report of the effects of complement suppres-

sion with pexelizumab on neurocognitive decline

after coronary artery bypass graft surgery. Stroke

35:2335-2339, 2004.

147. Harmon DC, Ghori KG, Eustace NP, et al: Apotinin

decreases the incidence of cognitive deficit following

CABG and cardiopulmonary bypass: a pilot rando-

mized controlled study. Can J Anaesth 51:1002-

1009, 2004.

148. O’Dwyer PJ, Serpell MG, Millar K, et al: Local or

general anesthesia for open hernia repair: A rando-

mised trial. Ann Surg 237:574-579, 2003.

149. Casati A, Aldegheri G, Vinciguerra F, et al: Rando-

mized comparison between sevoflurane anaesthesia

and unilateral spinal anaesthesia in elderly patients

undergoing orthopaedic surgery. Eur J Anaesth

20:640-646, 2003.

150. Somprakit P, Lertakyamanee J, Satraratanamai C,

et al: Mental state change after general and regional

anesthesia in adults and elderly patients: A rando-

mized clinical trial. J Med Assoc Thai 85(Suppl

3)S875-S883, 2002.

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