Table of Contents Table of Contents
Previous Page  303 / 2894 Next Page
Information
Show Menu
Previous Page 303 / 2894 Next Page
Page Background

165. Antzelevitch C: Molecular biology and cellular

mechanisms of Brugada and long QT syndromes in

infants and young children. J Electrocardiol

34(Suppl):177–181, 2001.

166. Li J, Correa AM: Kinetic modulation of HERG

potassium channels by the volatile anesthetic halo-

thane. Anesthesiology 97:921–930, 2002.

167. Davies LA, Hopkins PM, Boyett MR, et al: Effects of

halothane on the transient outward K(+) current in

rat ventricular myocytes. Br J Pharmacol 131:223–

230, 2000.

168. Sirois JE, Lynch C III, Bayliss DA: Convergent and

reciprocal modulation of a leak K

+

current and I(h)

by an inhalational anaesthetic and neurotransmit-

ters in rat brainstem motoneurones. J Physiol

541:717–729, 2002.

169. Chen X, Sirois JE, Lei Q, et al: HCN subunit-specific

and cAMP-modulated effects of anesthetics on neu-

ronal pacemaker currents.J Neurosci 25:5803–5814,

2005.

170. Robinson RB, Siegelbaum SA: Hyperpolarization-

activated cation currents: From molecules to phy-

siological function. Annu Rev Physiol 65:453–480,

2003.

171. Girault JA, Hemmings HC Jr: Cell signaling.

In

Hemmings HC Jr., Hopkins PM (eds): Foundations

of Anesthesia, 2nd Edition. London, Mosby, 2005,

pp 31–50.

172. Rebecchi MJ, Pentyala SN: Anaesthetic actions on

other targets: protein kinase C and guanine nucleo-

tide-binding proteins. Br J Anaesth 89:62–78, 2002.

173. Peterlin Z,IshizawaY,Araneda R,et al: Selective acti-

vation of G-protein–coupled receptors by volatile

anesthetics. Mol Cell Neurosci 30:506–512, 2005.

174. Minami K, Gereau RW, Minami M, et al: Effects of

ethanol and anesthetics on type 1 and 5 metabotro-

pic glutamate receptors expressed in

Xenopus laevis

oocytes. Mol Pharmacol 53:148–156, 1998.

175. Minami K, Minami M, Harris RA: Inhibition of

5-hydroxytryptamine type 2A receptor-induced

currents by n-alcohols and anesthetics. J Pharmacol

Exp Ther 281:1136–1143, 1997.

176. Minami K, Vanderah TW, Minami M, et al: Inhibi-

tory effects of anesthetics and ethanol on muscari-

nic receptors expressed in

Xenopus

oocytes. Eur J

Pharmacol 339:237–244, 1997.

177. Hemmings HC Jr: General anesthetic effects on

protein kinase C. Toxicol Lett 100:89–95, 1998.

178. Hasegawa J, Takekoshi S, Nagata H, et al: Sevoflu-

rane stimulates MAP kinase signal transduction

through the activation of PKC alpha and betaII in

fetal rat cerebral cortex cultured neuron. Acta His-

tochem Cytochem 39:163–172, 2006.

179. Das J, Addona GH, Sandberg WS, et al: Identifica-

tion of a general anesthetic binding site in the dia-

cylglycerol-binding domain of protein kinase

C-delta. J Biol Chem 279:37964–37972, 2004.

180. Shumilla JA, Sweitzer SM, Eger EI 2nd, et al: Inhibi-

tion of spinal protein kinase C-epsilon or -gamma

isozymes does not affect halothane minimum alveo-

lar anesthetic concentration in rats. Anesth Analg

99:82–84, 2004.

181. Sonner JM,Gong D,Li J,et al: Mouse strainmodestly

influences minimum alveolar anesthetic concentra-

tion and convulsivity of inhaled compounds.Anesth

Analg 89:1030–1034, 1999.

182. Snyder GL, Galdi S, Hendrick JP, et al: General anes-

thetics selectively modulate glutamatergic and

dopaminergic signaling via site-specific phos-

phorylation in vivo. Neuropharmacology 53:619–

630, 2007.

183. Hemmings HC Jr, Adamo AI: Effects of halothane

and propofol on purified brain protein kinase C

activation. Anesthesiology 81:147–155, 1994.

184. Marota JJ, Crosby G, Uhl GR: Selective effects of

pentobarbital and halothane on c-fos and jun-B

gene expression in rat brain. Anesthesiology

77:365–371, 1992.

185. Hamaya Y, Takeda T, Dohi S, et al: The effects of

pentobarbital,isoflurane,and propofol on immediate-

early gene expression in the vital organs of the rat.

Anesth Analg 90:1177–1183, 2000.

186. Culley DJ, Yukhananov RY, Xie ZC, et al: Altered

hippocampal gene expression 2 days after general

anesthesia in rats. Eur J Pharmacol 549:71–78,

2006.

187. Fütterer CD, Maurer MH, Schmitt A, et al: Altera-

tions in rat brain proteins after desflurane anesthe-

sia. Anesthesiology 100:302–308, 2004.

188. Nicoll RA, Madison DV: General anesthetics hyper-

polarize neurons in the vertebrate central nervous

system. Science 217:1055–1057, 1982.

189. Southan AP, Wann KT: Inhalation anaesthetics

block accommodation of pyramidal cell discharge

in the rat hippocampus. Br J Anaesth 63:581–586,

1989.

190. Fujiwara N, Higashi H, Nishi S, et al: Changes in

spontaneous firing patterns of rat hippocampal neu-

rones induced by volatile anaesthetics. J Physiol

(Lond) 402:155–175, 1988.

191. Kullmann DM, Martin RL, Redman SJ: Reduction

by general anaesthetics of group Ia excitatory posts-

ynaptic potentials and currents in the cat spinal

cord. J Physiol (Lond) 412:277–296, 1989.

192. MacIver MB, Roth SH: Inhalation anaesthetics

exhibit pathway-specific and differential actions on

hippocampal synaptic responses in vitro. Br J

Anaesth 60:680–691, 1988.

193. Ries CR, Puil E: Ionic mechanism of isoflurane’s

actions on thalamocortical neurons. J Neurophysiol

81:1802–1809, 1999.

194. Semyanov A,Walker MC,Kullmann DM,et al: Toni-

cally active GABA(A) receptors: Modulating gain

and maintaining the tone. Trends Neurosci 27:262–

269, 2004.

195. Bai D, Zhu G, Pennefather P, et al: Distinct functio-

nal and pharmacological properties of tonic and

quantal inhibitory postsynaptic currents mediated

by

g

-aminobutyric acid

A

receptors in hippocampal

neurons. Mol Pharmacol 59:814–824, 2001.

196. Bieda MC,MacIver MB: Major role for tonic GABA

A

conductances in anesthetic suppression of intrinsic

neuronal excitability. J Neurophysiol 92:1658–1667,

2004.

197. Caraiscos VB, Elliott EM, You T, et al: Tonic inhibi-

tion in mouse hippocampal CA1 pyramidal neurons

is mediated by

a

5 subunit-containing gamma-

aminobutyric acid type A receptors. Proc Natl Acad

Sci U S A 101:3662–3667, 2004.

198. Caraiscos VB, Newell JG, You T, et al: Selective

enhancement of tonic GABAergic inhibition in

murine hippocampal neurons by low concentra-

tions of the volatile anesthetic isoflurane. J Neurosci

24:8454–8458, 2004.

199. Cheng VY, Martin LJ, Elliott EM, et al: Alpha5GA-

BA

A

receptors mediate the amnestic but not sedati-

ve-hypnotic effects of the general anesthetic

etomidate. J Neurosci 26:3713–3720, 2006.

200. Berg-Johnsen J,Langmoen IA:The effect of isoflurane

on excitatory synaptic transmission in the rat hippo-

campus. Acta Anaesthesiol Scand 36:350–355, 1992.

201. Kirson ED, Yaari Y, Perouansky M: Presynaptic and

postsynaptic actions of halothane at glutamatergic

synapses in the mouse hippocampus. Br J Pharma-

col 124:1607–1614, 1998.

202. Richards CD, Smaje JC: Anaesthetics depress the

sensitivity of cortical neurones to L-glutamate. Br J

Pharmacol 58:347–357, 1976.

203. Wakamori M, Ikemoto Y, Akaike N: Effects of two

volatile anesthetics and a volatile convulsant on the

excitatory and inhibitory amino acid responses in

dissociated CNS neurons of the rat. J Neurophysiol

66:2014–2021, 1991.

204. Yang J, Zorumski CF: Effects of isoflurane on

N

-me-

thyl-d-aspartate gated ion channels in cultured rat

hippocampal neurons. Ann NY Acad Sci 625:287–

289, 1991.

205. de Sousa SLM, Dickinson R, Lieb WR, et al: Con-

trasting synaptic actions of the inhalational general

anesthetics isoflurane and xenon. Anesthesiology

92:1055–1066, 2000.

206. Dildy-Mayfield JE,Eger EI 2nd,Harris RA:Anesthetics

produce subunit-selective actions on glutamate recep-

tors. J Pharmacol Exp Ther 276:1058–1065, 1996.

207. Minami K, Wick MJ, Stern-Bach Y, et al: Sites of

volatile anesthetic action on kainate (Glutamate

receptor 6) receptors. J Biol Chem 273:8248–8255,

1998.

208. Banks MI, Pearce RA: Dual actions of volatile anes-

thetics on GABA(A) IPSCs: Dissociation of bloc-

king and prolonging effects. Anesthesiology

90:120–134, 1999.

209. Murugaiah KD, Hemmings HC Jr: Effects of intra-

venous general anesthetics on [3H]GABA release

from rat cortical synaptosomes. Anesthesiology

89:919–928, 1998.

210. Nishikawa K,MacIver MB:Agent-selective effects of

volatile anesthetics on GABA(A) receptor-mediated

synaptic inhibition in hippocampal interneurons.

Anesthesiology 94:340–347, 2001.

211. Westphalen RI,Hemmings HC: Selective depression

by general anesthetics of glutamate versus GABA

release from isolated cortical nerve terminals.

J Pharmacol Exp Ther 304:1188–1196, 2003.

212. Westphalen RI, Hemmings HC Jr: Volatile anesthe-

tic effects on glutamate versus GABA release from

isolated rat cortical nerve terminals: basal release.

J Pharmacol Exp Ther 316:208–215, 2006.

213. Nagele P, Mendel JB, PlaczekWJ, et al: Volatile anes-

thetics bind rat synaptic snare proteins. Anesthesio-

logy 103:768–778, 2005.

214. van Swinderen B, Saifee O, Shebester L, et al: A

neomorphic syntaxin mutation blocks volatile-

anesthetic action in

Caenorhabditis elegan

s. Proc

Natl Acad Sci U S A 96:2479–2484, 1999.

215. Pittson S, Himmel AM, MacIver MB: Multiple

synaptic and membrane sites of anesthetic action in

the CA1 region of rat hippocampal slices. BMC

Neurosci 5:52, 2004.

216. Eckenhoff ME, Chan K, Eckenhoff RG: Multiple

specific binding targets for inhaled anesthetics in

the mammalian brain. J Pharmacol Exp Ther

300:172–179, 2002.

217. Pearce RA, Stringer JL, Lothman EW: Effect of vola-

tile anesthetics on synaptic transmission in the rat

hippocampus. Anesthesiology 71:591–598, 1989.

218. Pearce RA: Volatile anaesthetic enhancement of

paired-pulse depression investigated in the rat

hippocampus in vitro. J Physiol 492:823–840,

1996.

219. Malenka RC, Bear MF: LTP and LTD: An emba-

rrassment of riches. Neuron 44:5–21, 2004.

220. Simon W, Hapfelmeier G, Kochs E, et al: Isoflurane

blocks synaptic plasticity in the mouse hippocam-

pus. Anesthesiology 94:1058–1065, 2001.

221. Desmond NL, Colbert CM, Zhang DX, et al:

NMDA receptor antagonists block the induction of

long-term depression in the hippocampal dentate

gyrus of the anesthetized rat. Brain Res 552:93–98,

1991.

222. Maren S, Baudry M, Thompson RF: Differential

effects of ketamine and MK-801 on the induction of

long-term potentiation. Neuroreport 2:239–242,

1991.

223. Jinks SL, Atherley RJ, Dominguez CL, et al: Isoflu-

rane disrupts central pattern generator activity and

coordination in the lamprey isolated spinal cord.

Anesthesiology 103:567–575, 2005.

224. Munglani R,Andrade J,Sapsford DJ,et al:Ameasure

of consciousness and memory during isoflurane

administration: The coherent frequency. Br J

Anaesth 71:633–641, 1993.

225. Traub RD, Spruston N, Soltesz I, et al: Gamma-fre-

quency oscillations: A neuronal population pheno-

menon, regulated by synaptic and intrinsic cellular

processes, and inducing synaptic plasticity. Prog

Neurobiol 55:563–575, 1998.

226. Dickinson R, Awaiz S, Whittington MA, et al: The

effects of general anaesthetics on carbachol-

evoked gamma oscillations in the rat hippocam-

pus in vitro. Neuropharmacology 44:864–872,

2003.

227. Antkowiak B, Hentschke H: Cellular mechanisms of

gamma rhythms in rat neocortical brain slices

probed by the volatile anaesthetic isoflurane. Neu-

rosci Lett 231:87–90, 1997.

Anestésicos inhalatorios: mecanismos de acción

303

10

Sección II

Farmacología y anestesia

© ELSEVIER. Fotocopiar sin autorización es un delito