Miller Anestesia

394 / 2894

and cytoprotective mechanisms. Br J Anaesth
91:551–565, 2003.
55. Zaugg M,Lucchinetti E,Garcia C,et al:Anaesthetics
and cardiac preconditioning. Part II. Clínicas impli-
cations. Br J Anaesth 91:566–576, 2003.
56. Tanaka K, Ludwig LM, Kersten JR, et al: Mecha-
nisms of cardioprotection by volatile anesthetics.
Anesthesiology 100:707–721, 2004.
57. De Hert SG, Turani F, Mathur S, et al: Cardioprotec-
tion with volatile anesthetics: Mechanisms and clí-
nicas implications. Anesth Analg 100:1584–1593,
2005.
58. Schlack W, Preckel B, Stunneck D, et al: Effects of
halothane, enflurane, isoflurane, sevoflurane and
desflurane on myocardial reperfusion injury in the
isolated rat heart. Br J Anaesth 81:913–919, 1998.
59. Patel HH, Ludwig LM, Fryer RM, et al: Delta opioid
agonists and volatile anesthetics facilitate cardiopro-
tection via potentiation of KATP channel opening.
FASEB J 16:1468–1470, 2002.
60. Ludwig LM, Weihrauch D, Kersten JR, et al: Protein
kinase C translocation and Src protein tyrosine
kinase activation mediate isoflurane-induced pre-
conditioning in vivo: Potential downstream targets
of mitochondrial KATP channels and reactive oxygen
species. Anesthesiology 100:532–539, 2004.
61. Zhong C, Zhou Y, Liu H: Nuclear factor kB and
anesthetic preconditioning during myocardial
ischemia-reperfusion. Anesthesiology 100:540–
546, 2004.
62. Hausenloy DJ,Yellon DM: New directions for pro-
tecting the heart against ischaemia-reperfusion
injury: Targeting the reperfusion injury salvage
kinase (RISK)-pathway. Cardiovasc Res 61:448–
460, 2004.
63. Inagaki N, Gonoi T, Clement JP, et al: Reconstitu-
tion of IKATP: An inward rectifier subunit plus the
sulfonylurea receptor. Science 270:1166–1170,
1995.
64. Suzuki M, Sasaki N, Miki T, et al: Role of sarcolem-
mal KATP channels in cardioprotection against ische-
mia/reperfusion injury in mice. J Clin Invest
109:509–516, 2002.
65. Sato T, Sasaki N, Seharaseyon J, et al: Selective
pharmacological agents implicate mitochondrial
but not sarcolemmal KATP channels in ischemic
cardioprotection. Circulation 101:2418–2423,
2000.
66. Dos Santos P, Kowaltowski AJ, Laclau MN, et al:
Mechanisms by which opening the mitochondrial
ATP-sensitive K+ channel protects the ischemic
heart. Am J Physiol Heart Circ Physiol 283:H284–
H295, 2002.
67. Holmuhamedov EL, Wang L, Terzic A: ATP-sen-
sitive K+ channel openers prevent Ca2+ overload
in rat cardiac mitochondria. J Physiol 519:347–
360, 1999.
68. Green DR, Reed JC: Mitochondria and apoptosis.
Science 281:1309–1312, 1998.
69. Gottlieb RA, Engler RL: Apoptosis in myocardial
ischemia-reperfusion. Ann N Y Acad Sci 874:412–
426, 1999.
70. Ozcan C, Bienengraeber M, Dzeja PP, et al:
Potassium channel openers protect cardiac
mitochondria by attenuating oxidant stress at
reoxygenation. Am J Physiol Heart Circ Physiol
282:H531–H539, 2002.
71. Minners J, Lacerda L, McCarthy J, et al: Ischemic
and pharmacological preconditioning in Girardi
cells and C2C12 myotubes induce mitochondrial
uncoupling. Circ Res 89:787–792, 2001.
72. Halestrap AP: The regulation of the matrix volume
of mammalian mitochondria in vivo and in vitro
and its role in the control of mitochondrial metabo-
lism. Biochim Biophys Acta 973:355–382, 1989.
73. Garlid KD: Cation transport in mitochondria—the
potassium cycle. Biochim Biophys Acta 1275:123–
126, 1996.
74. Holmuhamedov EL, Jovanovic S, Dzeja PP, et al:
Mitochondrial ATP-sensitive K+ channels modulate
cardiac mitochondrial function. Am J Physiol Heart
Circ Physiol 275:H1567–H1576, 1998.
75. Costa AD, Quinlan CL, Andrukhiv A, et al: The
direct physiological effects of mitochondrial KATP
opening on heart mitochondria.Am J Physiol Heart
Circ Physiol 290:H406–H415, 2006.
76. Sergeev P, da Silva R, Lucchinetti E, et al: Trigger-
dependent gene expression profiles in cardiac pre-
con for distinct genetic programs
in ischemic and anesthetic preconditioning. Anes-
thesiology 100:474–488, 2004.
77. Tanaka K,Weihrauch D,Ludwig LM,et al: Mitochon-
drial adenosine triphosphate–regulated potassium
channel opening acts as a trigger for isoflurane-indu-
ced preconditioning by generating reactive oxygen
species. Anesthesiology 98:935–943, 2003.
78. Roscoe AK,Christensen JD,Lynch C 3rd: Isoflurane,
but not halothane, induces protection of human
myocardium via adenosine A1 receptors and adeno-
sine triphosphate–sensitive potassium channels.
Anesthesiology 92:1692–1701, 2000.
79. Toller WG, Gross ER, Kersten JR, et al: Sarcolemmal
and mitochondrial adenosine triphosphate–depen-
dent potassium (KATP) channels. Mechanism of
desflurane-induced cardioprotection. Anesthesio-
logy 92:1731–1739, 2000.
80. Hanouz JL, Yvon A, Massetti M, et al: Mechanisms
of desflurane-induced preconditioning in isolated
human right atria in vitro. Anesthesiology 97:33–41,
2002.
81. Kwok WM, Martinelli AT, Fujimoto K, et al: Diffe-
rential modulation of the cardiac adenosine tri-
phosphate–sensitivepotassiumchannelbyisoflurane
and halothane. Anesthesiology 97:50–56, 2002.
82. Han J, Kim E, Ho WK, et al: Effects of volatile anes-
thetic isoflurane on ATP-sensitive K+ channels in
rabbit ventricular myocytes. Biochem Biophys Res
Commun 229:852–856, 1996.
83. Aizawa K, Turner LA, Weihrauch D, et al: Protein
kinase C-εprimes the cardiac sarcolemmal adeno-
sine triphosphate–sensitive potassium channel to
modulation by isoflurane.Anesthesiology 101:381–
389, 2004.
84. Turner LA, Fujimoto K, Suzuki A, et al: The interac-
tion of isoflurane and protein kinase C–activators
on sarcolemmal KATP channels. Anesth Analg
100:1680–1686, 2005.
85. An J, Stadnicka A, Kwok WM, et al: Contribution
of reactive oxygen species to isoflurane-induced
sensitization of cardiac sarcolemmal adenosine
triphosphate–sensitive potassium channel to
pinacidil. Anesthesiology 100:575–580, 2004.
86. Stadnicki A, Bosjnak ZJ: Isoflurane decreases ATP
sensitivity of guinea pig cardiac sarcolemmal KATP
channel at reduced intracellular pH. Anesthesio-
logy 98:396–403, 2003.
87. Marinovic J, Bosjnak ZJ, Stadnicka A: Distinct roles
of sarcolemmal and mitochondial adenosine tri-
phosphate–sensitive potassium channels in isoflura-
ne-induced protection against oxidative stress.
Anesthesiology 105:98–104, 2006.
88. Marinovic J, Bosnjak ZJ, Stadnicka A: Preconditio-
ning by isoflurane induces lasting sensitization of
the cardiac sarcolemmal adenosine triphosphate–
sensitive potassium channel by a protein kinase
C-d–mediated mechanism. Anesthesiology
103:540–547, 2005.
89. Stadnicka A, Marinovic J, Bienengraeber M, et al:
Impact of in vivo preconditioning by isoflurane on
adenosine triphosphate–sensitive potassium chan-
nels in the rat heart: Lasting modulation of nucleo-
tide sensitivity during early memory period.
Anesthesiology 104:503–510, 2006.
90. Bienengraeber M, Warltier DC, Bosnjak ZJ, et al:
Mechanism of cardiac sarcolemmal adenosine tri-
phosphate–sensitive potassium channel activation
by isoflurane in a heterogenous expression system.
Anesthesiology 105:534–540, 2006.
91. Kohro S, Hogan QH, Nakae Y, et al: Anesthetic
effects on mitochondrial ATP-sensitive K channel.
Anesthesiology 95:1435–1440, 2001.
92. Nakae Y, Kwok WM, Bosnjak ZJ, et al: Isoflurane
activates rat mitochondrial ATP-sensitive K+ chan-
nels reconstituted in lipid bilayers. Am J Physiol
Heart Circ Physiol 284:H1865–H1871, 2003.
93. Nakae Y, Kohro S, Hogan QH, et al: Intracellular
mechanismof mitochondrial adenosine triphospha-
te–sensitive potassium channel activation with iso-
flurane. Anesth Analg 97:1025–1032, 2003.
94. Gross GJ, Peart JN: KATP channels and myocardial
preconditioning: An update. Am J Physiol Heart
Circ Physiol 285:H921–H930, 2003.
95. Crystal GJ, Zhou X, Gurevicius J, et al: Direct coro-
nary vasomotor effects of sevoflurane and desflurane
in in situ canine hearts. Anesthesiology 92:1103–
1113, 2000.
96. Piriou V, Ross S, Pigott D, et al: Beneficial effect of
concomitant administration of isoflurane and nico-
randil. Br J Anaesth 79:68–77, 1997.
97. TollerWG,Kersten JR,Gross ER,et al: Isoflurane pre-
conditions myocardium against infarction via activa-
tion of inhibitory guanine (Gi) nucleotide binding
proteins. Anesthesiology 92:1400–1407, 2000.
98. Kersten JR, Orth KG, Pagel PS, et al: Role of adeno-
sine in isoflurane-induced cardioprotection. Anes-
thesiology 86:1128–1139, 1997.
99. Wakeno-Takahashi M, Otani H, Nakao S, et al: Ade-
nosine and a nitric oxide donor enhances cardio-
protection by preconditioning with isoflurane
through mitochondrial adenosine triphosphate–
sensitive K+ channel-dependent and -independent
mechanisms. Anesthesiology 100:515–524, 2004.
100. Ishizawa Y, Pidikiti R, Liebman PA, et al: G protein–
coupled receptors as direct targets of inhaled anes-
thetics. Mol Pharmacol 61:945–952, 2002.
101. Lange M, Smul TM, Blomeyer CA, et al: Role of the
b1-adrenergic pathway in anesthetic and ischemic
preconditioning against myocardial infarction in
the rabbit heart in vivo. Anesthesiology 105:503–
510, 2006.
102. Liu H, McPherson BC, Yao Z: Preconditioning atte-
nuates apoptosis and necrosis: Role of protein
kinase C-epsilon and -delta isoforms. Am J Physiol
Heart Circ Physiol 281:H404–H410, 2001.
103. Toller WG, Montgomery MW, Pagel PS, et al: Isoflu-
rane-enhanced recovery of canine stunned myocar-
dium: Role for protein kinase C? Anesthesiology
91:713–722, 1999.
104. Fujimoto K, Bosnjak ZJ, Kwok WM: Isoflurane-
induced facilitation of the cardiac sarcolemmal KATP
channel. Anesthesiology 97:57–65, 2002.
105. Light PE, Bladen C, Winkfein RJ, et al: Molecular
basis of protein kinase C–induced activation of
ATP-sensitive potassium channels. Proc Natl Acad
Sci USA 97:9058–9063, 2000.
106. Uecker M,Da Silva R,Grampp T,et al: Translocation
of protein kinase C isoforms to subcellular targets
in ischemic and anesthetic preconditioning. Anes-
thesiology 99:138–147, 2003.
107. Novalija E, Kevin LG, Camara AK, et al: Reactive
oxygen species precede the epsilon isoform of
protein kinase C in the anesthetic preconditio-
ning signaling cascade. Anesthesiology 99:421–
428, 2003.
108. Obal D, Weber NC, Zacharowski K, et al: Role of
protein kinase C-εin isoflurane-induced cardiopro-
tection. Br J Anaesth 94:166–173, 2005.
109. Toma O,Weber NC,Wolter JI, et al: Desflurane pre-
conditioning induces time-dependent activation of
protein kinase C epsilon and extracellular-signal
regulated kinase 1 and 2 in the rat heart in vivo.
Anesthesiology 101:1372–1380, 2004.
110. Bouwman RA, Musters RJ, van Beek-Harmsen BJ,
et al: Reactive oxygen species precede protein
394 Farmacología y anestesia II