38. Billard V, Gambus PL, Chamoun N, et al: A compa-
rison of spectral edge, delta power, and bispectral
index as EEG measures of alfentanil, propofol, and
midazolam drug effect. Clin Pharmacol Ther 61:45–
58, 1997.
39. Schnider TW, Minto CF, Fiset P, et al: Semilinear
canonical correlation applied to the measurement of
the electroencephalographic effects of midazolam
and flumazenil reversal. Anesthesiology 84:510–519,
1996.
40. Egan TD, Muir KT, Hermann DJ, et al: The electro-
encephalogram (EEG) and clinical measure of
opioid potency: Defining the EEG–clinical potency
relationship (“fingerprint”) with application to
remifentanil. Int J Pharm Med 15:1–9, 2001.
41. Ausems ME, Hug CC Jr, Stanski DR, et al: Plasma
concentrations of alfentanil required to supplement
nitrous oxide anesthesia for general surgery. Anes-
thesiology 65:362–373, 1986.
42. Glass PSA, Doherty M, Jacobs JR, et al: Plasma con-
centration of fentanyl, with 70% nitrous oxide, to
prevent movement at skin incision. Anesthesiology
78:842–847, 1993.
43. Gourlay GK, Kowalski SR, Plummer JL, et al: Fen-
tanyl blood concentration analgesic response rela-
tionship in the treatment of postoperative pain.
Anesth Analg 67:329–337, 1988.
44. Van den Nieuwenhuyzen MCO, Engbers FHM,
Burm AGL, et al: Computer-controlled infusion of
alfentanil versus PCA-morphine for postoperative
analgesia: A double-blind study. Anesth Analg
40:1112–1118, 1995.
45. Lehmann KA: Patient-controlled analgesia for posto-
perative pain. Adv Pain Res Ther 14:297, 1990.
46. Lehmann KA, Gerhard A, Horrichs-Haermeyer G,
et al: Postoperative patient-controlled analgesia
with sufentanil: Analgesic efficacy and minimum
effective concentrations. Acta Anaesthesiol Scand
35:221, 1991.
47. Ropcke H, Schwilden H: The interaction of nitrous
oxide and enflurane on the EEG median of 2-3 Hz
is additive, but weaker than at 1.0 MAC. Anaesthe-
sist 45:819–825, 1996.
48. Gonsowski CT, Eger EI 2nd: Nitrous oxide
minimum alveolar anesthetic concentration in rats
is greater than previously reported. Anesth Analg
79:710–712, 1994.
49. Deady JE, Koblin DD, Eger EI 2nd, et al: Anesthetic
potencies and the unitary theory of narcosis.Anesth
Analg 60:380–384, 1981.
50. Targ AG,Yasuda N, Eger EI 2nd, et al: Halogenation
and anesthetic potency. Anesth Analg 68:599–602,
1989.
51. Kissin I: General anesthetic action: An obsolete
notion? Anesth Analg 76:215–218, 1993.
52. Hendrickx JFA, Eger EI 2nd, Sonner JM, Shafer SL:
Is synergy the rule? A review of anesthetic interac-
tions producing hypnosis and immobility. Anesth
Analg 107:494–506, 2008.
53. Katoh T, Ikeda I: The effects of fentanyl on sevoflu-
rane requirements for loss of consciousness and
skin incision. Anesthesiology 88:18–24, 1998.
54. McEwan AI, Smith C, Dyar O, et al: Isoflurane MAC
reduction by fentanyl. Anesthesiology 78:864–869,
1993.
55. Brunner MD, Braithwaite P, Jhaveri R, et al: The
MAC reduction of isoflurane by sufentanil. Br J
Anaesth 72:42–46, 1994.
56. Westmoreland C, Sebel PS, Groper A, et al: Reduc-
tion of isoflurane MAC by fentanyl or alfentanil.
Anesthesiology 77:A394, 1992.
57. Lang E, Kapila A, Shlugman D, et al: Reduction of
isoflurane minimal alveolar concentration by remi-
fentanil. Anesthesiology 85:721–728, 1996.
58. Glass PSA, Jacobs JR, Smith RL, et al: Pharmacoki-
netic model–driven infusion of
fentanyl:Assessmentof accuracy. Anesthesiology 73:1082–1090, 1990.
59. Dwyer R, Bennett HL, Eger EI 2nd, et al: Isoflurane
anesthesia prevents unconscious learning. Anesth
Analg 75:107–112, 1992.
60. Minto CF, Schnider TW, Short TG, et al: Response
surface model for anesthetic drug interactions.
Anesthesiology 92:1603–1616, 2000.
61. Shafer SL, Varvel JR: Pharmacokinetics, pharmaco-
dynamics, and rational opioid selection. Anesthe-
siology 74:53–63, 1991.
62. Henthorn TK, Krejcie TC, Shanks CA, et al: Time-
dependent distribution volume and kinetics of the
pharmacodynamic effector site.J Pharm Sci 81:1136,
1992.
63. Wagner JG: A safe method for rapidly achieving
plasma concentration plateaus. Clin Pharmacol
Ther 16:691–700, 1974.
64. Bruhn J, Bouillon TW, Ropcke H, Hoeft A: A
manual slide rule for target-controlled infusion of
propofol: Development and evaluation. Anesth
Analg 96:142–147, 2003.
65. Hughes MA, Glass PSA, Jacobs JR: Context-sensi-
tive half-time in multicompartment pharmacokine-
tic models for intravenous anesthetic drugs.
Anesthesiology 76:334–341, 1992.
66. Schwilden H: Optimization of the dosage of volatile
anesthetics based on pharmacokinetic and dynamic
models. Anasth Intensivther Notfallmed 20:307–
315, 1985.
67. Fisher DM, Rosen JI: A pharmacokinetic explana-
tion for increasing recovery time following larger or
repeated doses of nondepolarizing muscle relaxants.
Anesthesiology 65:286–291, 1986.
68. Youngs EJ, Shafer SL: Pharmacokinetic parameters
relevant to recovery from opioids. Anesthesiology
81:833–842, 1994.
69. Bailey JM: Technique for quantifying the duration
of intravenous anesthetic effect. Anesthesiology
83:1095–1103, 1995.
70. Vuyk J, Mertens MJ, Olofsen E, et al: Propofol anes-
thesia and rational opioid selection: Determination
of optimal EC
50
-EC
95
propofol-opioid concentra-
tions that assure adequate anesthesia and a rapid
return of consciousness. Anesthesiology 87:1549–
1562, 1997.
71. Crankshaw DP, Morgan DJ, Beemer GH, et al: Pre-
programmed infusion of alfentanil to constant arte-
rial plasma concentration. Anesth Analg 76:556,
1993.
72. Shafer SL: Constant versus optimal plasma concen-
trations. Anesth Analg 76:467–469, 1993.
73. Reves JG, Jacobs JR, Glass PSA: Automated drug
delivery in anesthesia. In: ASA Refresher Course in
Anesthesiology. San Francisco, American Society of
Anesthesiologists, 1991, p 19.
74. Kruger-Thiemer E: Continuous intravenous infu-
sion and multicompartment accumulation. Eur J
Pharmacol 4:317–324, 1968.
75. Schwilden H,Schuttler J,Stoekel H: Pharmacokinetics
as applied to total intravenous a
naesthesia:Theoreticalconsiderations. Anaesthesia 38(Suppl):51–52, 1983.
76. Schüttler J, Schwilden H, Stoekel H: Pharmacokine-
tics as applied to total intravenous anaesthesia:
Practical implications. Anaesthesia 38(Suppl):53–
56, 1983.
77. Bazaral MG, Ciarkowski A: Food and drug admi-
nistration regulations and computer-controlled
infusion pumps. Int Anesthesiol Clin 33:45–63,
1995.
78. Shafer SL, Siegel LC, Cooke JE, et al: Testing com-
puter-controlled infusion pumps by simulation.
Anesthesiology 68:261–266, 1988.
79. Hu C, Horstman DJ, Shafer SL: Variability of target-
controlled infusion is less than the variability after
bolus injection. Anesthesiology 102:639–645, 2005.
80. Varvel JR, Donoho DL, Shafer SL: Measuring the
predictive performance of computer-controlled
infusion pumps. J Pharmacokinet Biopharm 20:63,
1992.
81. Raemer DB, Buschman A,Varvel JR, et al: The pros-
pective use of population pharmacokinetics in a
computer-driven infusion system for alfentanil.
Anesthesiology 73:66–72, 1990.
82. Schüttler J, Kloos S, Schwilden H, et al: Total intra-
venous anaesthesia with propofol and alfentanil by
computer-assisted
infusion.
Anaesthesia
43(Suppl):2–7, 1988.
83. Lemmens HJM, Bovill JG, Burm AGL, et al: Alfen-
tanil infusion in the elderly. Anaesthesia 43:850–
856, 1988.
84. Veselis RA, Glass P, Dnistrian A, et al: Performance
of computer-assisted continuous infusion at low
concentrations of intravenous sedatives. Anesth
Analg 84:1049–1057, 1997.
85. Shafer SL,Varvel SL,Aziz N, et al: The pharmacokine-
tics of fentanyl administered by computer controlled
infusion pump. Anesthesiology 73:1091–1102, 1990.
86. Alvis JM, Reves JG, Govier AV, et al: Computer
assisted continuous infusions of fentanyl during
cardiac anesthesia: Comparison with a manual
method. Anesthesiology 63:41–49, 1985.
87. Coetzee JF, Glen JB, Wium CA, et al: Pharmacoki-
netic model selection for target controlled infusions
of propofol: Assessment of three parameter sets.
Anesthesiology 82:1328–1345, 1995.
88. Marsh B,White M, Morton N, et al: Pharmacokine-
tic model driven infusion of propofol in children.
Br J Anaesth 67:41, 1991.
89. Tackley RM, Lewis GTR, Prys-Roberts C, et al:
Computer controlled infusion of propofol. Br J
Anaesth 62:46, 1989.
90. McClain DA, Hug CC Jr: Intravenous fentanyl kine-
tics. Clin Pharmacol Ther 28:106–114, 1980.
91. Ginsberg B, Howell S, Glass PSA, et al: Pharmaco-
kinetic model–driven infusion of fentanyl in chil-
dren. Anesthesiology 85:1268–1275, 1996.
92. Fiset P, Mathers L, Engstrom R, et al: Pharmacoki-
netics of computer controlled alfentanil administra-
tion in children undergoing cardiac surgery.
Anesthesiology 83:944–955, 1995.
93. Bailey JM, Mora CT, Shafer SL, et al: Pharmacoki-
netics of propofol in adult patients undergoing
coronary
revascularization.
Anesthesiology
81:1288–1297, 1996.
94. Wu J, Zhu SM, He HL, et al: Plasma propofol con-
centrations during orthotopic liver trasplantation.
Acta Anaesthesiol Scand 49:804–819, 2005.
95. Vuyk J, Oostwouder CJ, Vletter AA, et al: Gender
differences in the pharmacokinetics of propofol in
elderly patients during and after continuous infu-
sion. Br J Anaesth 86:183–188, 2001.
96. Schuttler J, Ihmsen H: Population pharmacokinetics
of propofol: A multicenter study. Anesthesiology
92:727–738, 2000.
97. Kazama T, Kurita T, Morita K, et al: Influence of
hemorrhage on propofol pseudo–steady state con-
centration. Anesthesiology 97:1156–1161, 2002.
98. Egan TD, Kuramkote S, Gong G, et al: Fentanyl
pharmacokinetics in hemorrhagic shock: A porcine
model. Anesthesiology 91:156–166, 1999.
99. Johnson KB, Kern SE, Hamber EA, et al: Influence
of hemorrhagic shock on remifentanil: A pharma-
cokinetic and pharmacodynamic analysis. Anesthe-
siology 94:322–332, 2001.
100. Pavlin DJ, Coda B, Shen DD, et al: Effects of com-
bining propofol and alfentanil on ventilation, anal-
gesia, sedation, and emesis in human volunteers.
Anesthesiology 84:23–37, 1996.
101. Kharasch ED, Russell M, Mautz D, et al: The role of
cytochrome P450 3A4 in alfentanil clearance.Anes-
thesiology 87:36–50, 1997.
102. Vuyk J, Mertens MJ, Vletter AA, et al: Alfentanil
modifies the pharmacokinetics of propofol in
volunteers. Anesthesiology 87:A300, 1997.
103. Bouillon T, Bruhn J, Radu-Radulescu L, et al: Non–
steady state analysis of the pharmacokinetic interac-
tion
between
propofol
and
remifentanil.
Anesthesiology 97:1350–1362, 2002.
104. Knibbe CA,Zuideveld KP,DeJongh J,et al: Population
pharmacokinetic and pharmacodynamic modeling of
propofol for long-term sedation in critically ill
patients:A comparison between propofol 6% and pro-
pofol 1%. Clin Pharmacol Ther 72:670–684, 2002.
105. Hill HF, Saeger L, Bjurstrom R, et al: Steady-state
infusions of opioids in human volunteers. I. Phar-
macokinetic tailoring. Pain 43:57, 1990.
106. Maitre PE,Stanski DR: Bayesian forecasting improves
the prediction of intraoperative plasma concentra-
tions of alfentanil. Anesthesiology 69:652–659, 1988.
107. Wakeling HG, Zimmerman JB, Howell S, Glass PS:
Targetingeffectcompartmentorcentralcompartment
concentration of
propofol:Whatpredicts loss of cons-
ciousness? Anesthesiology 90:92–97, 1999.
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Farmacología y anestesia
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